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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Yerba mate extract (Ilex paraguariensis) attenuates both central and peripheral inflammatory effects of diet-induced obesity in rats

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Autor(es):
Pimentel, Gustavo D. [1] ; Lira, Fabio S. [1] ; Rosa, Jose C. [1] ; Caris, Aline V. [1] ; Pinheiro, Fernanda [1] ; Ribeiro, Eliane B. [1] ; Oller do Nascimento, Claudia M. [1] ; Oyama, Lila M. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, UNIFESP EPM, BR-04023062 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 24, n. 5, p. 809-818, MAY 2013.
Citações Web of Science: 29
Resumo

To clarify the effects of natural dietary components on the metabolic consequences of obesity, we examined the effects of yerba mate extract Ilex paraguariensis on both central and peripheral inflammatory effects of diet-induced obesity and correlated the hypothalamic tumor necrosis factor (TNF)-alpha level with adipose depot weight. Wistar rats were divided into four groups: a control group (CTL) fed with chow diet, a second group fed with chow diet plus yerba mate extract (CTL+E), a third group fed with a high-fat diet rich in saturated fatty acids (HFD) and a fourth group fed with HFD plus yerba mate extract (HFD+E). Enzyme-linked immunosorbent assay, Western blotting, colorimetric method and treatment by gavage were utilized as materials and methods. The HFD groups showed a significant increase in food intake (kcal), body weight, adipose tissue and leptin level in comparison to CTL and CTL+E. HFD leads to increase of both central and peripheral inflammatory effects, and deregulation of insulin pathway. In addition, yerba mate extract intake blunted the proinflammatory effects of diet-induced obesity in rats by reducing the phosphorylation of hypothalamic IKK and NFKBp65 expression and increasing the protein levels of IKBoe, the expression of adiponectin receptor-1 and consequently the amount of IRS-2. Moreover, the increase in interleukin (IL)-6 levels in the liver and muscle and of the IL-10/TNF-alpha ratio in groups that received yerba mate extract showed the anti-inflammatory effects of this natural substance. Taken together, our data suggest that the use of yerba mate extract may be useful for reducing low-grade obesity-associated inflammation. (C) 2013 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 09/11398-0 - Efeito da administração de extrato de chá mate Ilex paraguariensis, sobre o perfil lipídico e resposta glicêmica de ratos tratados com dieta hiperlipídica
Beneficiário:Aline Venticinque Caris
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 09/14373-8 - Estudo dos efeitos da galato-3-epigalocatequina sobre a secreção de adipocinas, a via de sinalização do TLR4 e do NF-°B em adipócitos: estudo in vivo e in vitro
Beneficiário:Lila Missae Oyama
Linha de fomento: Auxílio à Pesquisa - Regular