Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters

Texto completo
Autor(es):
Sinzato, Yuri Karen [1] ; Volpato, Gustavo Tadeu [2] ; Iessi, Isabela Lovizutto [1] ; Bueno, Aline [1] ; Paranhos Calderon, Iracema de Mattos [1] ; Cunha Rudge, Marilza Vieira [1] ; Damasceno, Debora Cristina [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista Unesp, Dept Gynecol & Obstet, Botucatu Med Sch, Lab Expt Res Gynecol & Obstet, Botucatu, SP - Brazil
[2] Mato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Inst Biol & Hlth Sci, BR-78600000 Barra Do Garcas, MG - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Experimental Diabetes Research; 2012.
Citações Web of Science: 25
Resumo

The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women. (AU)

Processo FAPESP: 06/03768-3 - Análise morfológica e imunológica das placentas de ratas com diabete de intensidade moderada
Beneficiário:Débora Cristina Damasceno
Linha de fomento: Auxílio à Pesquisa - Regular