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Total serum N-glycans mark visceral leishmaniasis in human infections with Leishmania infantum

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Autor(es):
Porcino, Gabriane Nascimento ; Bladergroen, Marco Rene ; Dotz, Viktoria ; Nicolardi, Simone ; Memarian, Elham ; Gardinassi, Luiz Gustavo ; Costa, Carlos Henrique Nery ; Almeida, Roque Pacheco de ; Santos, Isabel Kinney Ferreira de Miranda ; Wuhrer, Manfred
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: ISCIENCE; v. 26, n. 7, p. 24-pg., 2023-07-21.
Resumo

Visceral leishmaniasis (VL) is a clinical form of leishmaniasis with high mortality rates when not treated. Diagnosis suffers from invasive techniques and suboptimal sensitivities. The current (affordable) treatment with pentavalent antimony as advised by the WHO is possibly harmful to the patient. There is need for an improved diagnosis to prevent possibly unnecessary treatment. N-glycan analysis may aid in diagnosis. We evaluated the N-glycan profiles from active VL, asymptomatic infections (ASYMP) and controls from non-endemic (NC) and endemic (EC) areas. Active VL has a distinct N-glycome profile that associates with disease severity. Our study suggests that the observed glycan signatures could be a valuable additive to diagnosis and assist in identifying possible markers of disease and understanding the pathogenesis of VL. Further studies are warranted to assess a possible future role of blood glycome analysis in active VL diagnosis and should aim at disease specificity. (AU)

Processo FAPESP: 19/19789-0 - Estudos exploratórios sobre fatores que afetam os desfechos de infecções de humanos com Leishmania infantum
Beneficiário:Isabel Kinney Ferreira de Miranda Santos
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/18527-3 - O papel da N-glicosilação da região FC de IgG na patogênese da Leishmania visceral e a avaliação de novas estratégias terapêuticas
Beneficiário:Gabriane Nascimento Porcino
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/07820-9 - Padrões de N-Glicosilação de Regiões Fc de IgG: Papel na regulação da resposta imune contra a Leishmania infantum e aplicação em estratégias terapêuticas para o calazar
Beneficiário:Isabel Kinney Ferreira de Miranda Santos
Modalidade de apoio: Auxílio à Pesquisa - Regular