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Short-term stressors and corticosterone effects on immunity in male toads (Rhinella icterica): A neuroimmune-endocrine approach

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Titon, Stefanny Christie Monteiro ; Titon Junior, Braz ; Gomes, Fernando Ribeiro ; Assis, Vania Regina
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH; v. 13, p. 10-pg., 2021-05-01.

In the last decades, it is growing the idea that stress-induced immunomodulation is bimodal: with acute stress associated with enhancing effects while chronic stress with suppressive effects. However, the immune-endocrine interactions and its implications are often overlooked in ectotherms. We investigated the impact of corticosterone (CORT) treatment and short-term stressors on CORT plasma levels and the immunity of male toads (Rhinella icterica), using three distinct protocols: restraint, immune challenge (with lipopolysaccharide, LPS), and CORT transdermal application (TA). Our results showed increased CORT and neutrophil: lymphocyte ratio (NLR) regardless of the stress input (restraint, LPS challenge) or CORT TA. In the meantime, the bacterial killing ability (BKA) was not affected by any treatment, suggesting this immune parameter might be a more constitutive and robust response. Interestingly, the cellular immune response showed distinct patterns. Increased phagocytosis of blood leukocytes and phytohemagglutinin edema followed LPS and CORT TA (15 & mu;g), respectively. In contrast, the phagocytosis of peritoneal leukocytes decreased after CORT TA (1 and 10 & mu;g), indicating that short-term increases in CORT levels might impair local immune function. Such differences in cellular immunity might also be associated with CORT doses or the interaction between CORT and other immune mediators, such as melatonin, testosterone, and cytokines. Overall, our results highlight the immune-enhancing effects of the acute stress response and CORT TA, and the complexity of the immune-endocrine interaction in anurans. It also highlights the relevance of investigating distinct contexts for CORT increase arising from different situations, as well as diverse immune components for a better understanding of the stress-induced immunomodulation. (AU)

Processo FAPESP: 13/00900-1 - Estudo comparativo das relações entre imunocompetência e níveis plasmáticos de esteróides inter-renais e gonadais em sapos
Beneficiário:Fernando Ribeiro Gomes
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/23801-4 - Efeitos imuno-moduladores do estresse agudo em sapos do Gênero Rhinella
Beneficiário:Vania Regina de Assis
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/16320-7 - Impactos das mudanças climáticas e ambientais sobre a fauna: uma abordagem integrativa
Beneficiário:Carlos Arturo Navas Iannini
Modalidade de apoio: Auxílio à Pesquisa - Programa de Pesquisa sobre Mudanças Climáticas Globais - Temático
Processo FAPESP: 16/01782-0 - Relações entre as condições ambientais e fisiológicas de atividade e sua importância para alterações da distribuição de sapos frente às mudanças climáticas
Beneficiário:Braz Titon Junior
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado