Busca avançada
Ano de início
Entree


Dietary intervention with avocado (Persea americana Mill.) ameliorates intestinal inflammation induced by TNBS in rats

Texto completo
Autor(es):
de Oliveira, Ellen Cristina Souza ; Dalmau, Lesvi Moya ; de Almeida Costa, Celso Acacio Rodrigues ; de Almeida Junior, Luiz Domingues ; Ballard, Cintia Reis ; Marostica Junior, Mario Roberto ; Stahl, Marcella Aparecida ; Grimaldi, Renato ; Witaicenis, Aline ; Di Stasi, Luiz Claudio
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: INFLAMMOPHARMACOLOGY; v. N/A, p. 14-pg., 2022-12-31.
Resumo

Nutritional interventions have been shown to be an interesting approach for the treatment of chronic diseases, including inflammatory bowel disease (IBD). Persea americana Mill. (avocado), is a potential food to be used for the prevention or treatment of intestinal inflammation, due to its nutritional value and pharmacological effects. In this study we evaluated if the dietary intervention with avocado fruit pulp could as an intestinal anti-inflammatory diet using a trinitrobenzenesulfonic acid (TNBS) model of intestinal inflammation in rats. For this purpose, 5, 10 or 20% of avocado fruit pulp was incorporated in the diet of rats, for 21 days before and 7 days after TNBS-induced intestinal inflammation. Dietary intervention with avo-cado fruit pulp (20%) decreased the extension of colonic lesions (1.38 +/- 0.99 vs. 2.67 +/- 0.76 cm), weight/length colon ratio (151.03 +/- 31.45 vs. 197.39 +/- 49.48 cm), inhibited myeloperoxidase activity (891.2 +/- 243.2 vs 1603 +/- 158.2 U/g), reduced tumor necrosis factor-alpha (53.94 +/- 6.45 vs. 114.9 +/- 6.21 pg/mg), interleukin-1 beta (583.6 +/- 106.2 vs. 1259 +/- 81.68 pg/mg) and interferon gamma (27.95 +/- 2.97 vs. 47.79 +/- 3.51 pg/mg) levels and prevented colonic glutathione depletion (2585 +/- 77.2 vs 1778 +/- 167.2 nmol/g). The consumption of enriched diet with 20% avocado pulp by 28 days did not promote any alterations in the biochemical or behavioral parameters evaluated. Avocado showed intestinal anti-inflammatory activity, modulating immune response, and acting as antioxidant. The dietary intervention with avocado was safe, suggesting its potential as a complementary treatment in intestinal inflammation. (AU)

Processo FAPESP: 19/13465-8 - Parceria entre a Universidade de Lund e a Universidade Estadual de Campinas para estudos em alimentos funcionais e dietas na prevenção de doenças cardiometabólicas
Beneficiário:Mário Roberto Maróstica Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
Beneficiário:Glaucia Maria Pastore
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos
Beneficiário:Mário Roberto Maróstica Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/13320-9 - Efeito do azeite da polpa e do chá das folhas do abacate da variedade Hass associado à atividade física no tratamento da obesidade induzida por dieta hiperlipídica
Beneficiário:Mário Roberto Maróstica Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular