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Fipronil exposure compromises respiration and damages the Malpighian tubules of the stingless bee Partamona helleri Friese (Hymenoptera: Apidae)

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Farder-Gomes, Cliver Fernandes ; Santos, Abraao Almeida ; Fernandes, Kenner Morais ; Bernardes, Rodrigo Cupertino ; Martins, Gustavo Ferreira ; Serrao, Jose Eduardo
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Environmental Science and Pollution Research; v. 29, n. 58, p. 8-pg., 2022-07-12.

Fipronil has been widely used in agriculture and forestry in Brazil to control several pests. However, this insecticide may be hazardous to non-target organisms, including stingless bees, which are essential pollinators of crops and natural environments. Here, we investigated the effect of 24-h acute oral exposure to LC50 of fipronil on the Malpighian tubules of the stingless bee Partamona helleri (Friese). Insecticide exposure decreases the respiration rate of forager bees, and the Malpighian tubules are severely affected, as shown by the epithelial architecture disorganization, loss of cytoplasmic content, degradation of the brush border, and nuclear pyknosis. In addition, fipronil ingestion increases the number of Malpighian cells positive for peroxidase, LC3, cleaved caspase-3, and JNK. However, Notch and ERK1/2-positive cells decrease in the exposed bees. These changes in the signaling proteins indicate an increase in oxidative stress, autophagy and apoptosis, and impairment of cell recovery. Overall, our results demonstrate the toxicological effects of fipronil on a stingless bee, which compromises the physiology of this important pollinator. (AU)

Processo FAPESP: 17/21097-3 - Interações abelha-agricultura: perspectivas para a utilização sustentável
Beneficiário:Osmar Malaspina
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
Processo FAPESP: 21/09996-8 - Efeito de agrotóxicos no sistema imune de abelhas sem ferrão (Hymenoptera: Meliponini)
Beneficiário:Cliver Fernandes Farder Gomes
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado