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Gene expression data of inflammatory mediators in apical periodontitis in 129 (wild type) and 5-lipoxygenase knockout mice

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Taira, Thaise Mayumi ; Ribeiro, Vitor Luis ; Silva Ribeiro, Yuri Jivago ; Bezerra da Silva, Raquel Assed ; Bezerra da Silva, Lea Assed ; Lucisano Politi, Marilia Pacifico ; Faccioli, Lucia Helena ; Garcia Paula-Silvaa, Francisco Wanderley
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: DATA IN BRIEF; v. 40, p. 8-pg., 2022-02-01.

Apical periodontitis is an immune inflammatory response around periapical tissues as a result of pathogens invasion into the root canal. The host immunoinflammatory response could determine the progression of this disease, which involves the recruitment of immune cells, and the release of several cytokines in the lesion site. The 5-lipoxygenase pathway has been activated in some osteolytic diseases due to its capacity to interfere in the proliferation and differentiation of bone cells, including the osteoclasts. As mean to understand the inflammatory genes regulation in the apical periodontitis progression, we evaluated the network of 66 genes related to cytokines, chemokines and other inflammatory mediators and receptors in the wildtype (WT) and 5-lipoxygenase enzyme genetically deficient mice (KO). This article presents data not published but related to the research article "Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis". (C) 2022 The Author(s). Published by Elsevier Inc. (AU)

Processo FAPESP: 19/00204-1 - Papel do fator de necrose tumoral-alfa na inflamação e no reparo pulpar e periapical
Beneficiário:Francisco Wanderley Garcia de Paula e Silva
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/17611-4 - Mecanismos envolvidos na modulação da via 5-lipoxigenase na lesão periapical experimentalmente induzida
Beneficiário:Francisco Wanderley Garcia de Paula e Silva
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores