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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

oronaVac and ChAdOx1 Vaccination and Gamma Infection Elicited Neutralizing Antibodies against the SARS-CoV-2 Delta Varian

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Autor(es):
Fumagalli, Marcilio Jorge [1] ; Castro-Jorge, Luiza Antunes [1] ; de Souza, William Marciel [2] ; de Azevedo, Patrick Orestes [3] ; Hansen, Alana Witt [4] ; Gazzinelli, Ricardo Tostes [3] ; da Fonseca, Benedito Antonio Lopes [1] ; Spilki, Fernando Rosado [4] ; Figueiredo, Luiz Tadeu Moraes [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Virol Res Ctr, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Texas Med Branch, World Reference Ctr Emerging Viruses & Arboviruse, Dept Microbiol & Immunol, Galveston, TX 77555 - USA
[3] Univ Sao Paulo, Platform Translat Med Oswaldo Cruz Fdn, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto - Brazil
[4] Feevale Univ Novo Hamburgo, Hlthy Sci Inst, Mol Microbiol Lab, BR-93525075 Novo Hamburgo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: IRUSES-BASE; v. 14, n. 2 FEB 2022.
Citações Web of Science: 0
Resumo

The emergence of new SARS-CoV-2 variants represents a constant threat to world public health. The SARS-CoV-2 Delta variant was identified in late 2020 in India; since then, it has spread to many other countries, replacing other predominant lineages and raising concerns about vaccination efficiency. We evaluated the sensitivity of the Delta variant to antibodies elicited by COVID-19 vaccinated (CoronaVac and ChAdOx1) and convalescent individuals previously infected by earlier lineages and by the Gamma variant. No reduction in the neutralizing efficacy of the Delta variant was observed when compared to B lineage and a reduced neutralization was observed for the Gamma variant. Our results indicate that neutralization of the Delta variant is not compromised in individuals vaccinated by CoronaVac or ChAdOx1; however, a reduction in neutralization efficacy is expected for individuals infected by the Gamma variant, highlighting the importance of continuous vaccination even for previously infected individuals. (AU)

Processo FAPESP: 18/09383-3 - Estudo sobre epitopos de Flavivirus com importância médica no Brasil e de seus anticorpos
Beneficiário:Marcilio Jorge Fumagalli
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 20/05527-0 - Vacina intranasal bivalente utilizando vírus influenza expressando a proteína S (spike) do SARS-CoV-2: mecanismos de proteção e lesão pulmonar
Beneficiário:Ricardo Tostes Gazzinelli
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/26119-0 - Vírus emergentes e reemergentes: biologia, patogênese e prospecção
Beneficiário:Eurico de Arruda Neto
Linha de fomento: Auxílio à Pesquisa - Temático