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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

an Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF

Texto completo
Autor(es):
Goulart, Cassia da Luz [1] ; Caruso, Flavia Rossi [1] ; de Araujo, Adriana Sanches Garcia [1] ; Moura, Silvia Cristina Garcia de [2] ; Catai, Aparecida Maria [2] ; Agostoni, Piergiuseppe [3] ; Mendes, Renata Goncalves [1] ; Arena, Ross [4] ; Borghi-Silva, Audrey [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos UFSCar, Cardiopulm Physiotherapy Lab, Physiotherapy Dept, Sao Carlos - Brazil
[2] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiovasc Phys Therapy Lab, Sao Carlos - Brazil
[3] Univ Milan, Ctr Cardiol Monzino, Dept Clin Sci & Community Hlth, Cardiovasc Sect, Milan - Italy
[4] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, Chicago, IL - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN CARDIOVASCULAR MEDICINE; v. 8, JAN 31 2022.
Citações Web of Science: 0
Resumo

Aim: To evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF).\& nbsp;Methods and Results: On separate days, patients performed incremental cardiopulmonary exercise testing and two constant-work rate tests receiving NIPPV or controlled ventilation (SHAM) (the bilevel mode-Astral 150) in random order until the limit of tolerance (Tlim). During exercise, oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) were assessed using near-infrared spectroscopy (Oxymon, Artinis Medical Systems, Einsteinweg, The Netherlands). NIPPV associated with high-intensity exercise caused a significant increase in exercise tolerance, peak oxygen consumption (V \& BULL;O2 in mlO(2)\& BULL;kg(-1)\& BULL;min(-1)), minute ventilation peak (V \& BULL;E in ml/min), peak peripheral oxygen saturation (SpO(2), %), and lactate/tlim (mmol/s) when compared with SHAM ventilation. In cerebral, respiratory, and peripheral muscles, NIPPV resulted in a lower drop in OxyHb+Mb (p < 0.05) and an improved deoxygenation response DeoxyHb+Mb (p < 0.05) from the half of the test (60% of Tlim) when compared with SHAM ventilation.\& nbsp;Conclusion: Non-invasive positive pressure ventilation during constant work-rate exercise led to providing the respiratory muscle unloading with greater oxygen supply to the peripheral muscles, reducing muscle fatigue, and sustaining longer exercise time in patients with COPD-HF. (AU)

Processo FAPESP: 20/13465-5 - Identificação de variáveis prognósticas do teste de exercício cardiopulmonar para estratificar gravidade da insuficiência cardíaca
Beneficiário:Cássia da Luz Goulart
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
Processo FAPESP: 18/03233-0 - Estudo da interação cardiorrespiratória e da oferta de oxigênio periférica e cerebral como moduladores da capacidade de exercício durante a aplicação do binível na coexistência da DPOC-ICC
Beneficiário:Cássia da Luz Goulart
Linha de fomento: Bolsas no Brasil - Doutorado Direto