haracterization and Biological Performance of Mari... - BV FAPESP
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haracterization and Biological Performance of Marine Sponge Collage

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Autor(es):
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Fernandes, Kelly Rossetti [1] ; Parisi, Julia Risso [1] ; Cruz, Matheus de Almeida [2] ; Gabbai-Armelin, Paulo Roberto [2] ; Tashiro de Araujo, Tiago Akira [2] ; Santana, Alan de Franca [2] ; Avanzi, Ingrid Regina [2] ; Silva-Freitas, Francisca Rayanne [2] ; Ribeiro, Alessandra Mussi [2] ; Aparecida do Vale, Giovanna Caroline [1] ; Fortulan, Carlos Alberto [3] ; Granito, Renata Neves [2] ; Muniz Renno, Ana Claudia [2]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Fed Univ Sao Carlos UFSCar, Dept Physiotherapy, Sao Carlos, SP - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Santos, SP - Brazil
[3] Sao Carlos Sch Engn, Dept Mech Engn, Sao Carlos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Brazilian Archives of Biology and Technology; v. 64, 2021.
Citações Web of Science: 0
Resumo

This study characterized the morphological aspects of marine collagen - spongin (SPG) extract from marine sponges, as well as, evaluating its in vitro and in vivo biological performance. Aplysina fulva marine sponge was used for the SPG extraction. It was investigated the physicochemical and morphological properties of SPG by using scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and compared to PMMA and bovine collagen. Additionally, the SPG cytotoxicity and its influence on cell proliferation, through in vitro tests. Moreover, the in vivo biological response was investigated using an experimental model of tibial bone defect. The results demonstrated that SPG presented an irregular granular aspect, with a composition of OH, C=O, NH, CN and an amorphous profile. Also, in vitro viability results for the L929 and MC3T3 cell lines cultured with SPG extracts demonstrated normal growth in comparison to controls, except for MC3T3 viability at day 3. For in vivo analysis, using tibial bone defects in rats, SPG treated animals presented an increased rate of material resorption and higher granulation and bone formation deposition in the region of the defect, mainly after 45 days. As a conclusion, SPG was successfully extracted. The in vitro and in vivo studies pointed out that SPG samples produced an increase in L929 and MC3T3 viability and improved the performance in tibial bone defects. It can be concluded that SPG can be used as a bone graft for bone regeneration. (AU)

Processo FAPESP: 16/13636-9 - Performance biológica de compósitos de espongina extraídas de esponjas marinhas enriquecidos com biosilicato associado ou não a laser terapia na engenharia do tecido ósseo
Beneficiário:Kelly Rossetti Fernandes
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/20704-8 - Efeitos de compósitos de biovidro/colágeno/magnésio no processo de reparo ósseo de ratos saudáveis
Beneficiário:Paulo Roberto Gabbai Armelin
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado