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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression

Texto completo
Autor(es):
Scarlet Marques de Oliveira [1] ; Jéssica Leite Garcia [2] ; Danielle Fernandes Vileigas [3] ; Dijon Henrique Salomé de Campos [4] ; Fabiane Valentini Francisqueti-Ferron [5] ; Artur Junio Togneri Ferron [6] ; Danielle Cristina Tomaz da Silva-Bertani [7] ; Carlos Roberto Padovani [8] ; Camila Renata Corrêa [9] ; Antonio Carlos Cicogna [10]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] São Paulo State University. Botucatu Medical School - Brasil
[2] São Paulo State University. Botucatu Medical School - Brasil
[3] São Paulo State University. Botucatu Medical School - Brasil
[4] São Paulo State University. Botucatu Medical School - Brasil
[5] São Paulo State University. Botucatu Medical School - Brasil
[6] São Paulo State University. Botucatu Medical School - Brasil
[7] São Paulo State University. Botucatu Medical School - Brasil
[8] São Paulo State University. Institute of Bioscience - Brasil
[9] São Paulo State University. Botucatu Medical School - Brasil
[10] São Paulo State University. Botucatu Medical School - Brasil
Número total de Afiliações: 10
Tipo de documento: Artigo Científico
Fonte: International Journal of Cardiovascular Sciences; 2021-07-26.
Resumo

Abstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change. (AU)

Processo FAPESP: 12/21024-2 - Influência da obesidade por dieta hiperlipídica saturada sobre os colágenos I e III miocárdico e a sua associação com o sistema renina-angiotensina via receptor tipo1 de angiotensina II (AT1)
Beneficiário:Danielle Cristina Tomaz da Silva
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/23954-0 - Expressão proteica dos colágenos tipo I e tipo III cardíaco de ratos resistentes à obesidade induzida por dieta hiperlipídica saturada
Beneficiário:Scarlet Marques de Oliveira
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica