Cellulose Nanofibers Improve the Performance of Re... - BV FAPESP
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Cellulose Nanofibers Improve the Performance of Retrograded Starch/Pectin Microparticles for Colon-Specific Delivery of 5-ASA

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Autor(es):
Meneguin, Andreia Bagliotti [1] ; Sabio, Rafael Miguel [1] ; de Souza, Mauricio Palmeira Chaves [1] ; Fernandes, Richard Perosa [1] ; de Oliveira, Anselmo Gomes [1] ; Chorilli, Marlus [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14800903 Araraquara, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: PHARMACEUTICS; v. 13, n. 9 SEP 2021.
Citações Web of Science: 0
Resumo

Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogradation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1-10 mu m and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16-98%) and drug loading (1.97-26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease. (AU)

Processo FAPESP: 19/19817-3 - Sistemas biorresponsivos baseados em amido retrogradado/pectina acrescidos de nanofibras de celulose como estratégia para liberação colônica do 5-ASA no tratamento da Doença Inflamatória Intestinal
Beneficiário:Andréia Bagliotti Meneguin
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
Beneficiário:Maria Vitória Lopes Badra Bentley
Modalidade de apoio: Auxílio à Pesquisa - Temático