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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association between thyroid function and Alzheimer's disease: A systematic review

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Autor(es):
Figueroa, Paulina Belen Sepulveda [1, 2] ; Ferreira, Ana Flavia Fernandes [3] ; Britto, Luiz Roberto [3] ; Doussoulin, Arlette Patricia [4] ; Torrao, Andrea da Silva [2]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ La Frontera, Fac Med, Dept Preclin Sci, Temuco - Chile
[2] Univ Sao Paulo, Dept Fisiol Biofis, Lab Neuronal Commun, Av Prof Lineu Prestes, 1524 Cidade Univ, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Fisiol Biofis, Lab Cellular Neurobiol, Av Prof Lineu Prestes, 1524 Cidade Univ0, BR-05508900 Sao Paulo, SP - Brazil
[4] Univ La Frontera, Dept Pediat & Child Surg, Temuco - Chile
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: METABOLIC BRAIN DISEASE; v. 36, n. 7, p. 1523-1543, OCT 2021.
Citações Web of Science: 1
Resumo

Alterations in metabolic parameters have been associated with an increased risk of dementia, among which thyroid function has gained great importance in Alzheimer's disease (AD) pathology in recent years. However, it remains unclear whether thyroid dysfunctions could influence and contribute to the beginning and/or progression of AD or if it results from AD. This systematic review was conducted to examine the association between thyroid hormone (TH) levels and AD. Medline, ISI Web of Science, EMBASE, Cochrane library, Scopus, Scielo, and LILACS were searched, from January 2010 to March 2020. A total of 17 articles were selected. The studies reported alterations in TH and circadian rhythm in AD patients. Behavior, cognition, cerebral blood flow, and glucose consumption were correlated with TH deficits in AD patients. Whether thyroid dysfunctions and AD have a cause-effect relationship was inconclusive, however, the literature was able to provide enough data to corroborate a relationship between TH and AD. Although further studies are needed in this field, the current systematic review provides information that could help future investigations. (AU)

Processo FAPESP: 20/02109-3 - Participação do canal TRPM2 na neurodegeneração e ativação microglial no modelo da Doença de Parkinson induzido por 6-hidroxidopamina
Beneficiário:Ana Flávia Fernandes Ferreira
Linha de fomento: Bolsas no Brasil - Doutorado