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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Propolis increases Foxp(3) expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study

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Autor(es):
Conte, Fernanda Lopes [1, 2] ; Tasca, Karen Ingrid [1] ; Santiago, Karina Basso [1] ; Cardoso, Eliza de Oliveira [1] ; Romagnoli, Graziela Gorete [1] ; Golim, Marjorie de Assis [2] ; Marques Braz, Aline Marcia [2] ; Berretta, Andresa Aparecida [3] ; de Souza, Lenice do Rosario [2] ; Sforcin, Jose Mauricio [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Biosci, Campus Botucatu, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Botucatu Med Sch, Campus Botucatu, Sao Paulo - Brazil
[3] Apis Flora Indl Coml Ltda, Res Dev & Innovat Lab, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BIOMEDICINE & PHARMACOTHERAPY; v. 142, OCT 2021.
Citações Web of Science: 0
Resumo

HIV infection and the prolonged use of antiretroviral therapy (ART) contribute to persistent inflammation and immune deregulation in people living with HIV/AIDS (PLWHA). Propolis is a bee product with plenty of biological properties, including immunomodulatory and anti-inflammatory action. This work aimed to evaluate possible changes in the immune/inflammatory response in PLWHA under ART after propolis intake. Asymptomatic PLWHA were double-blindly randomized into parallel groups receiving propolis (500 mg/day, n = 20) for 3 months or placebo (n = 20). Plasma cytokines (TNF-alpha, IL-2, IL-4, IL-6, IL-10 and IL17) were evaluated by cytometric bead array; cytokine production by PBMC (IFN-gamma, IL-5, IL-17, IL-10, IL-1(i, IL-18, and IL-33) was assessed by ELISA; gene expression (T-bet, GATA-3, ROR gamma t and Foxp3) was determined by RT-qPCR, and cell proliferation was analysed by flow cytometry using CFSE staining. The average of gender, age, CD4+/CD8+ T cell count, time of diagnosis and treatment were similar in both groups. No differences were observed in cytokine levels nor in inflammasome activation. However, Pearson's correlation showed that IL-10 was directly correlated to CD4+ T cell count and inversely to IFN-gamma after treatment with propolis. Foxp3 expression and lymphocyte proliferation increased in the propolis group. Data suggested that daily propolis consumption may improve the immune response and decrease the inflammatory status in asymptomatic PLWHA under ART. (AU)

Processo FAPESP: 17/14846-0 - Efeito da própolis em marcadores imunológicos, inflamatórios e de estresse oxidativo em pessoas que vivem com HIV/AIDS (PVHA) sob tratamento antirretroviral
Beneficiário:Karen Ingrid Tasca
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/24591-6 - Avaliação de parâmetros imunológicos, inflamatórios e bioquímicos em indivíduos infectados pelo HIV sob uso da terapia antirretroviral em associação com a própolis
Beneficiário:Fernanda Lopes Conte
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 18/04297-1 - Influência do uso da própolis no perfil metabólico de pessoas infectadas pelo HIV sob terapia antirretroviral
Beneficiário:Ana Claudia de Moura Moreira Alves
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica