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Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer

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Autor(es):
Santos, Nilton Jose [1, 2] ; Barquilha, Caroline Nascimento [1, 2] ; Barbosa, Isabela Correa [1, 2] ; Macedo, Rodrigo Tavares [3] ; Lima, Flavio Oliveira [3] ; Justulin, Luis Antonio [1] ; Barbosa, Guilherme Oliveira [2] ; Carvalho, Hernandes F. [2] ; Felisbino, Sergio Luis [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Inst Biosci Botucatu IBB, Dept Struct & Funct Biol, BR-18618689 Botucatu, SP - Brazil
[2] UNICAMP State Univ Campinas, Inst Biol IB, Dept Struct & Funct Biol, BR-13083970 Campinas, SP - Brazil
[3] Sao Paulo State Univ, Botucatu Sch Med FMB, BR-01049010 Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 16 AUG 2021.
Citações Web of Science: 0
Resumo

Prostate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new biomarkers are still needed. The expression pattern and protein tissue localization of proteoglycans of the syndecan family (SDC 1-4) and syntenin-1 (SDCBP) were determined in normal and prostatic tumor tissue from two genetically engineered mouse models and human prostate tumors. Studies were validated using SDC 1-4 and SDCBP mRNA levels and patient survival data from The Cancer Genome Atlas and CamCAP databases. RNAseq showed increased expression of Sdc1 in Pb-Cre4/Pten(f/f) mouse Pca and upregulation of Sdc3 expression and downregulation of Sdc2 and Sdc4 when compared to the normal prostatic tissue in Pb-Cre4/Trp53(f/f)-;Rb1(f/f) mouse tumors. These changes were confirmed by immunohistochemistry. In human PCa, SDC 1-4 and SDCBP immunostaining showed variable localization. Furthermore, Kaplan-Meier analysis showed that patients expressing SDC3 had shorter prostate-specific survival than those without SDC3 expression (log-rank test, p = 0.0047). Analysis of the MSKCC-derived expression showed that SDC1 and SDC3 overexpression is predictive of decreased biochemical recurrence-free survival (p = 0.0099 and p = 0.045, respectively), and SDC4 overexpression is predictive of increased biochemical recurrence-free survival (p = 0.035). SDC4 overexpression was associated with a better prognosis, while SDC1 and SDC3 were associated with more aggressive tumors and a worse prognosis. (AU)

Processo FAPESP: 16/09532-3 - Câncer de próstata: alterações nos proteoglicanos da família Sindecan, na enzima de estresse oxidativo sulfiredoxina e na enzima quinase de ciclo celular MELK
Beneficiário:Sérgio Luis Felisbino
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/19644-1 - Câncer de próstata: participação das vias da adiponectina e do colágeno tipo X
Beneficiário:Sérgio Luis Felisbino
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/26175-7 - Alterações estromais no câncer de próstata: estudo da família Sindecam em dois modelos de camundongos knockouts - Pten-/- e Rb1-/- Trp53-/-
Beneficiário:Nilton José dos Santos
Linha de fomento: Bolsas no Brasil - Mestrado