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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans

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Autor(es):
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Nunes, Kelly [1, 2] ; Maia, Maria Helena Thomaz [3] ; dos Santos, Eduardo Jose Melo [3] ; dos Santos, Sidney Emanuel Batista [3] ; Guerreiro, Joao Farias [3] ; Petzl-Erler, Maria Luiza [4] ; Bedoya, Gabriel [5] ; Gallo, Carla [6] ; Poletti, Giovanni [7] ; Llop, Elena [8] ; Tsuneto, Luiza [9] ; Bortolini, Maria Catira [10] ; Rothhammer, Francisco [11] ; Single, Richard ; Ruiz-Linares, Andres [12, 13, 14] ; Rocha, Jorge [2, 15] ; Meyer, Diogo [1, 2, 16]
Número total de Autores: 17
Afiliação do(s) autor(es):
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[1] Univ Sao Paulo, Dept Genet & Biol Evolut, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Genet & Evolutionary Biol, BR-05508 Sao Paulo, SP - Brazil
[3] Univ Fed Para, Inst Ciencias Biol, Belem, Para - Brazil
[4] Univ Fed Parana, Dept Genet, Curitiba, Parana - Brazil
[5] Univ Antioquia, Inst Biol, Medellin - Colombia
[6] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Lima - Peru
[7] Univ Peruana Cayetano Heredia, Fac Med, Lima - Peru
[8] Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago - Chile
[9] Univ Estadual Maringa, Dept Ciencias Bas Saude, Maringa, Parana - Brazil
[10] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS - Brazil
[11] Univ Tarapaca, Inst Alta Invest, Arica - Chile
[12] Univ Vermont, Dept Math & Stat, Burlington, VT - USA
[13] Fudan Univ, Sch Life Sci & Human Phenome Inst, Collaborat Innovat Ctr Genet & Dev, Minist Educ, Key Lab Contemporary Anthropol, Shanghai 200433 - Peoples R China
[14] D Aix Marseille Univ, CNRS, EFS, ADES, F-13007 Marseille - France
[15] Univ Porto, Fac Ciencias, Dept Biol, Porto - Portugal
[16] Univ Porto, Recursos Genet, CIBIO Ctr Invest Biodiversidade, Porto - Portugal
Número total de Afiliações: 16
Tipo de documento: Artigo Científico
Fonte: HUMAN IMMUNOLOGY; v. 82, n. 7, p. 523-531, JUL 2021.
Citações Web of Science: 0
Resumo

The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from 30 human populations, 28 of which are Native Americans, all of whom were typed for genomewide and MHC region microsatellites. We find greater differentiation in the MHC than in the remainder of the genome (FST-MHC = 0.130 and FST-Genomic = 0.087), and use a permutation approach to show that this difference is statistically significant, and not accounted for by confounding factors. This finding lies in the opposite direction to the expectation that balancing selection reduces population differentiation. We interpret our findings as evidence that selection favors different sets of alleles in distinct localities, leading to increased differentiation. Thus, balancing selection at HLA genes simultaneously increases intrapopulation polymorphism and inter-population differentiation in Native Americans. (C) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 09/09127-8 - Evolução molecular e genética de populações de genes HLA
Beneficiário:Diogo Meyer
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/09950-9 - Evolução de genes HLA: diferenciação populacional e sinais de seleção recente em populações nativas e miscigenadas do Brasil
Beneficiário:Kelly Nunes
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 07/54278-9 - Populações ameríndias da América do Sul: estudo multi-locus e interferência histórico-demográfica e seletiva
Beneficiário:Kelly Nunes
Modalidade de apoio: Bolsas no Brasil - Doutorado