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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching

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Autor(es):
Ortecho-Zuta, Uxua [1] ; de Oliveira Duque, Carla Caroline [1] ; de Oliveira Ribeiro, Rafael Antonio [1] ; Leite, Maria Luisa [1] ; Soares, Diana Gabriela [2] ; Hebling, Josimeri [3] ; Fraga Briso, Andre Luiz [4] ; Souza Costa, Carlos Alberto [5]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP - Brazil
[2] Sao Paulo Univ USP, Sch Dent, Dept Dent Endodont & Dent Mat, Bauru, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Dent, Dept Morphol & Pediat Dent, Araraquara, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Dent, Dept Restorat Dent, Aracatuba - Brazil
[5] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, Humaita St 1680, BR-14801385 Araraquara, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Esthetic and Restorative Dentistry; v. 33, n. 8 JUL 2021.
Citações Web of Science: 0
Resumo

Evaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (Delta E/Delta WI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (Delta E) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for Delta WI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching. (AU)

Processo FAPESP: 17/22739-9 - Desenvolvimento e análise de um scaffold bicamada para regeneração do complexo dentino-pulpar
Beneficiário:Carlos Alberto de Souza Costa
Modalidade de apoio: Auxílio à Pesquisa - Regular