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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Physical and functional well-being and symptoms of ovarian cancer in women undergoing first-line of chemotherapy: a one-year follow-up

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Autor(es):
Ferracini, Amanda Canato [1] ; Pereira, Gabriela [2] ; de Souza, Cinthia Madeira [3] ; dos Santos, Thiago Fortes Cabello [4] ; Sarian, Luis Otavio [5] ; Derchain, Sophie [5] ; Mazzola, Priscila Gava [6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Grad Program Med Sci, Fac Med Sci, Sch Med Sci, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Grad Program Pharmaceut Sci, 200 Candido Portinari, BR-13083871 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Grad Program Gerontol, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[4] Pontifical Catholic Univ Campinas, Ctr Life Sci, Fac Med, BR-13034685 Campinas, SP - Brazil
[5] Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[6] Univ Estadual Campinas, Fac Pharmaceut Sci, 200 Candido Portinari, BR-13083871 Campinas, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: SUPPORTIVE CARE IN CANCER; JUN 2021.
Citações Web of Science: 0
Resumo

Purpose Clinicopathological features and chemotherapy can influence the quality of life (QOL), women with ovarian cancer. This study aimed to evaluate the physical and functional well-being, and ovarian cancer-specific effects scores reported from QOL questionnaire among women with ovarian cancer at the time of in their initial diagnosis and access the scores trajectory of women receiving neoadjuvant and adjuvant chemotherapy. Methods This prospective study used cross-sectional analysis at baseline and longitudinal analysis from baseline to 12-month post-chemotherapy. QOL was evaluated at the baseline, at sixth cycle and 12-month post-chemotherapy using FACT-O questionnaire. Clinicopathological features and chemotherapy regime were evaluated and tested for associations with QOL measures. Results Of the 38 women enrolled in this study, 27 (80.1%) completed the questionnaire for 12 months. The multivariate linear regression results suggest, at the baseline, women with advance stage and presence of post-surgery residual disease showed lower scores in physical and functional well-being, ovarian cancer-specific effects, and FACT-O TOI domains (p < 0.05). Longitudinal analysis spanning over 12 months showed an improvement in mean physical well-being, functional well-being, and ovarian cancer-specific effects scores, independent of chemotherapy received (p < 0.05). Conclusions At the baseline, the clinicopathological features such as stage, presence of post-surgery residual disease, and type of chemotherapy correlated with on QOL scores. At one-year follow-up, women who underwent chemotherapy showed improvement in QOL regardless of the type of chemotherapy they received. Future prospective study with a larger group is recommended. (AU)

Processo FAPESP: 19/24093-4 - Marcadores relacionados ao microambiente tumoral em mulheres com carcinoma de ovário
Beneficiário:Thiago Fortes Cabello dos Santos
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 16/22335-2 - Avaliação de marcadores genéticos e qualidade de vida em mulheres com carcinoma de ovário
Beneficiário:Amanda Canato Ferracini
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 18/00070-2 - Avaliação do gene EPHA5 nos efeitos da neuropatia periférica induzida pelo paclitaxel em neurônios sensoriais derivados de células-tronco pluripotentes induzidas
Beneficiário:Amanda Canato Ferracini
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado