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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study

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Autor(es):
Rodrigues, Luiz Eduardo [1] ; Kishibe, Milena Miyoshi [1] ; Keller, Rogeria [2] ; dos Santos Caetano, Heliard Rodrigues [3] ; Rufino, Marcos Natal [4] ; Sanches, Osimar de Carvalho [5] ; Giometti, Ines Cristina [6] ; Giuffrida, Rogerio [7] ; Bremer-Neto, Hermann [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Oeste Paulista, Fac Med, Dept Funct Sci, Lab Physiol & Biophys, Presidente Prudente, SP - Brazil
[2] Univ Oeste Paulista, Fac Biol Sci, Dept Funct Sci, Lab Microbiol, Presidente Prudente, SP - Brazil
[3] Univ Oeste Paulista, Fac Physiotherapy, Dept Funct Sci, Lab Physiol, Presidente Prudente, SP - Brazil
[4] Univ Oeste Paulista, Fac Med, Dept Funct Sci, Lab Physiol, Presidente Prudente, SP - Brazil
[5] Univ Santo Amaro, Fac Vet Med, Dept Pathol, Sao Paulo - Brazil
[6] Univ Oeste Paulista, Fac Vet Med, Dept Reprod, Presidente Prudente, SP - Brazil
[7] Univ Oeste Paulista, Fac Vet Med, Dept Stat, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: VETERINARY WORLD; v. 14, n. 5, p. 1210-1219, MAY 2021.
Citações Web of Science: 0
Resumo

Background and Aim: The prebiotics. mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and sperniatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. Materials and Methods: In total. 128 male rats were used, randomly divided into four experimental groups (n=32): Control: MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1. 2, 3, and 4) and hormonal measurements and histological evaluations were performed. Results: The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. Conclusion: It was concluded that the three different MOS prebiotics brought forward sexual maturity. (AU)

Processo FAPESP: 12/19454-9 - Mananoligossacarídeos na medicina preventiva: estudos in vitro e in vivo
Beneficiário:Hermann Bremer Neto
Modalidade de apoio: Auxílio à Pesquisa - Regular