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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

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Autor(es):
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Banin, Renata Mancini [1] ; Forcelini Machado, Meira Maria [2] ; de Andrade, Iracema Senna [1] ; Testa Carvalho, Lorenza Oliveira [1] ; Hirata, Bruna Kelly Sousa [2] ; de Andrade, Heider Mendonca [2] ; Julio, Viviane da Silva [2] ; Figueiredo Borges Ribeiro, Jessica de Souza [2] ; Cerutti, Suzete Maria [2] ; Oyama, Lila Missae [1] ; Ribeiro, Eliane Beraldi [1] ; Telles, Monica Marques [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Rua Botucatu 862, Edificio Ciencias Biomed, 2 Andar, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Ciencias Biol, Setor Fisiol & Farmacol, Diadema, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 11, n. 1 JAN 8 2021.
Citações Web of Science: 1
Resumo

While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p=0.048 vs. Sham+GbE) while it decreased the latency to immobility (p=0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p=0.004) and increased the latency to immobility (p=0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p=0.047) and total cholesterol levels (p=0.022) were associated with anxious-like behaviours while body adiposity (p=0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause. (AU)

Processo FAPESP: 12/03172-4 - Obesidade e depressão na pós-menopausa: estudo em ratas dos efeitos da ovariectomia sobre aspectos comportamentais e da regulação central da ingestão alimentar
Beneficiário:Eliane Beraldi Ribeiro
Linha de fomento: Auxílio à Pesquisa - Regular