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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy

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Autor(es):
Cardoso, Fabrizio dos Santos [1] ; de Souza Oliveira Tavares, Cristiane [1] ; Araujo, Bruno Henrique Silva [2] ; Mansur, Fernanda [3] ; Lopes-Martins, Rodrigo Alvaro Brandao [4] ; Gomes da Silva, Sergio [5, 6, 1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Mogi das Cruzes, Nucleo Pesquisas Tecnol, Ave Candido Xavier de Almeida & Souza 200, BR-08780911 Sao Paulo, SP - Brazil
[2] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Biociencias LNBio, Campinas, SP - Brazil
[3] Hosp Israelita Albert Einstein, Ctr Expt Res, Sao Paulo, SP - Brazil
[4] Univ Brasil UB, Lab Biophoton & Expt Therapeut Hlth & Esthet, Sao Paulo, SP - Brazil
[5] Fundacao Cristiano Varella FCV, Hosp Canc Muriae, Muriae, MG - Brazil
[6] Ctr Univ UNIFAMINAS UNIFAMINAS, Muriae, MG - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Cellular and Molecular Neurobiology; MAR 2021.
Citações Web of Science: 0
Resumo

Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer's disease. Despite the promising benefits in the brain, little is known about the laser's effects in the absence of pathological conditions. We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step-down inhibitory avoidance task. Additionally, the levels of a panel of inflammatory cytokines and chemokines were quantified in two different brain regions: the cerebral cortex and the hippocampus. Young and aged rats submitted to transcranial laser exhibited better cognitive performance in Barnes maze than did control rats. Transcranial laser therapy decreased cortical levels of GM-CSF, IL-10, MCP-1, LIX, and TNF alpha in young rats and IL-5 in aged rats. High levels of IL-6, IL-10, and TNF-alpha were found in the cerebral cortex of aged rats submitted to transcranial laser. In the hippocampus, a decrease in IP-10 and fractalkine levels was observed in the aged rats from the laser group when compared to the aged rats from the control group. Our data indicate that transcranial photobiomodulation improves spatial learning and memory and alters the neuroinflammatory profile of young and aged rats' brains. (AU)

Processo FAPESP: 13/08028-1 - CEGH-CEL - Centro de Estudos do Genoma Humano e de Células-Tronco
Beneficiário:Mayana Zatz
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 17/16443-0 - Potencial terapêutico do laser de baixa intensidade no cérebro de ratos idosos
Beneficiário:Fabrízio dos Santos Cardoso
Linha de fomento: Bolsas no Brasil - Doutorado