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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Intravenous Regional Limb Perfusion in Standing and Recumbent Horses: A Comparative Radiographic Study

Texto completo
Autor(es):
Garcia, Adriana F. S. [1] ; Doria, Renata G. S. [2] ; Arantes, Julia A. [2] ; Reginato, Gustavo M. [2] ; Neubauer, Fernanda G. [3] ; Ribeiro, Gesiane [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] United Metropolitan Coll FMU, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP - Brazil
[3] GNVETS, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Equine Veterinary Science; v. 98, MAR 2021.
Citações Web of Science: 0
Resumo

Although pharmacokinetic studies of drugs administered by intravenous regional limb perfusion (IRLP) to treat equine orthopedic infections suggest efficient drug distribution in the limbs, it remains unclear whether drug perfusion is affected by the position of the horse during the procedure. This study compared the perfusion of a radiopaque contrast into tissues of the extremities of horses maintained in standing and recumbent positions during an IRLP. Radiopaque contrast was administered through IRLP into the cephalic vein of 10 healthy adult horses under general anesthesia and right lateral recumbency (RG) or under sedation and standing (SG). The same animals were used in both groups, respecting a two-week washout period. Sequential radiographic images were performed immediately at the beginning of contrast administration (T0) and after 10, 20, 30, 40, and 50 minutes. Tourniquets were removed after 30 minutes. The time required for the contrast to reach the hooves was compared between groups. Contrast reached the hooves faster in SG (114 +/- 15 seconds) compared with RG (236 +/- 29 seconds) (P < 0.5). SG showed more uniform perfusion of the limb vessels, whereas RG showed more deposition of the contrast in the lateral digital vein, with smaller amounts reaching the hooves. From T10 onward, soft tissue radiopacity increased, albeit more markedly in standing than in recumbent animals, remaining until T50. Contrast radiography evidenced that IRLP performed in standing position leads to a quicker and more uniform perfusion of the vasculature and a more noticeable diffusion to the tissues than in recumbent horses. (c) 2021 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 19/03193-0 - Resposta transitória de mediadores inflamatórios induzida por lipopolissacarídeo no sangue e líquido alantoideano de éguas gestantes.
Beneficiário:Renata Gebara Sampaio Dória
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/21430-9 - Avaliação da viabilidade da utilização do cateter totalmente implantado em membros de equinos
Beneficiário:Renata Gebara Sampaio Dória
Linha de fomento: Auxílio à Pesquisa - Regular