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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma

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Autor(es):
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Marhuenda-Munoz, Maria [1, 2, 3] ; Rinaldi de Alvarenga, Jose Fernando [4] ; Hernaez, Alvaro [1, 5, 6, 7] ; Tresserra-Rimbau, Anna [1, 2, 3] ; Martinez-Gonzalez, Miguel Angel [8, 1, 9] ; Salas-Salvado, Jordi [1, 10, 11, 12] ; Corella, Dolores [1, 13] ; Malcampo, Mireia [14] ; Martinez, Jose Alfredo [1, 15, 16] ; Alonso-Gomez, Angel M. [1, 17, 18] ; Warnberg, Julia [1, 19] ; Vioque, Jesus [20, 21] ; Romaguera, Dora [1, 22] ; Lopez-Miranda, Jose [1, 23] ; Estruch, Ramon [1, 24] ; Tinahones, Francisco J. [1, 25] ; Lapetra, Jose [1, 26] ; Serra-Majem, J. Lluis [1, 27, 28] ; Bueno-Cavanillas, Aurora [19, 29] ; Tur, Josep A. [1, 22, 30] ; Sanchez, Vicente Martin [16, 31] ; Pinto, Xavier [1, 32] ; Delgado-Rodriguez, Miguel [16, 33] ; Matia-Martin, Pilar [34] ; Vidal, Josep [35, 36] ; Vazquez, Clotilde [1, 37] ; Daimiel, Lidia [16] ; Ros, Emilio [1, 38] ; Serra-Mir, Merce [38] ; Vazquez-Ruiz, Zenaida [1, 9] ; Nishi, Stephanie K. [1, 10, 11, 12] ; Sorli, Jose V. [1, 13] ; Zomeno, Maria Dolores [6, 14] ; Zulet, Maria Angeles [1, 15, 16] ; Vaquero-Luna, Jessica [17, 18] ; Carabano-Moral, Rosa [39] ; Notario-Barandiaran, Leyre [20, 21] ; Morey, Marga [1, 22] ; Garcia-Rios, Antonio [1, 23] ; Gomez-Perez, Ana M. [1, 25] ; Santos-Lozano, Jose Manuel [1, 26] ; Buil-Cosiales, Pilar [1, 9, 40] ; Basora, Josep [1, 10, 12, 41] ; Portoles, Olga [1, 13] ; Schroder, Helmut [14, 20] ; Abete, Itziar [1, 15, 16] ; Salaverria-Lete, Itziar [17] ; Toledo, Estefania [18] ; Babio, Nancy [1, 10, 11, 12] ; Fito, Montse [1, 14] ; Martinez-Huelamo, Miriam [2, 3] ; Lamuela-Raventos, Rosa M. [1, 2, 3]
Número total de Autores: 52
Afiliação do(s) autor(es):
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[1] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029 - Spain
[2] Univ Barcelona, Dept Nutr Food Sci & Gastron, Sch Pharm & Food Sci, Santa Coloma De Gramenet 08921 - Spain
[3] Univ Barcelona, Inst Nutr & Food Safety INSA UB, XaRTA, Santa Coloma De Gramenet 08921 - Spain
[4] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Food Res Ctr FoRC, BR-05508000 Sao Paulo - Brazil
[5] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, N-0473 Oslo - Norway
[6] Univ Ramon Llull, Blanquerna Sch Hlth Sci, Barcelona 08025 - Spain
[7] August Pi Sunyer Biomed Res Ctr IDIBAPS, Barcelona 08036 - Spain
[8] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA
[9] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona 31008 - Spain
[10] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Reus 43204 - Spain
[11] Univ Hosp Sant Joan Reus, Nutr Unit, Reus 43201 - Spain
[12] Inst Invest Sanitaria Pere Virgili IISPV, Reus 43201 - Spain
[13] Univ Valencia, Dept Prevent Med, Valencia 46010 - Spain
[14] Inst Hosp del Mar Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona 08007 - Spain
[15] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Pamplona 31008 - Spain
[16] CEI UAM CSIC, Precis Nutr Program, IMDEA Food, Madrid 28049 - Spain
[17] Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Vitoria 01009 - Spain
[18] Univ Basque Country UPV EHU, Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria 01009 - Spain
[19] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Sch Hlth Sci, Dept Nursing, Malaga 29010 - Spain
[20] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029 - Spain
[21] Miguel Hernandez Univ, Unit Nutrit Epidemiol, ISABIAL FISABIO, Alicante 03010 - Spain
[22] Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca 07120 - Spain
[23] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba 14004 - Spain
[24] Univ Barcelona, Hosp Clin, Internal Med Serv, Barcelona 08036 - Spain
[25] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Virgen Victoria Hosp, Dept Endocrinol, Malaga 29010 - Spain
[26] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville 41010 - Spain
[27] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria 35016 - Spain
[28] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria 35016 - Spain
[29] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18016 - Spain
[30] Univ Balear Islands, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122 - Spain
[31] Univ Leon, Inst Biomed IBIOMED, Leon 24071 - Spain
[32] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona 08908 - Spain
[33] Univ Jaen, Div Prevent Med, Fac Med, Jaen 23071 - Spain
[34] Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Inst Invest Sanitaria, Madrid 28040 - Spain
[35] Inst Salud Carlos III ISCIII, CIBER Diabet Enfermedades Metabol CIBERDEM, Madrid 28029 - Spain
[36] Univ Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Hosp Clin, Dept Endocrinol, Barcelona 08036 - Spain
[37] Univ Autonoma, Inst Invest Biomed IISFJD, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Madrid 28040 - Spain
[38] Hosp Clin Barcelona, Dept Endocrinol & Nutr, Barcelona 08036 - Spain
[39] Serv Andaluz Salud, Unidad Gest Clin Arroyo Miel, Distrito Atenc Primaria Costa Sol, Benalmadena 29630 - Spain
[40] Serv Navarro Salud, Osasunbidea, Atenc Primaria, Pamplona 31003 - Spain
[41] IDIAP Jordi Gol Gurina, Reus 43202 - Spain
Número total de Afiliações: 41
Tipo de documento: Artigo Científico
Fonte: ANTIOXIDANTS; v. 10, n. 3 MAR 2021.
Citações Web of Science: 2
Resumo

Carotenoids are pigments contained mainly in fruit and vegetables (F\&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F\&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F\&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F\&V than in low consumers of these foods (+3.04 mu mol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 mu mol/L (-5.54; 0.16), p-value = 0.064). High consumption of F\&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high. (AU)

Processo FAPESP: 19/11324-8 - Avaliação dos efeitos do D-limoneno no metabolismo intermediário de camundongos - relação entre o metabolismo do D-limoneno e os efeitos na saúde
Beneficiário:José Fernando Rinaldi de Alvarenga
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
Beneficiário:Bernadette Dora Gombossy de Melo Franco
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs