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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fish Oil Enriched in EPA, but Not in DHA, Reverses the Metabolic Syndrome and Adipocyte Dysfunction Induced by a High-Fat Diet

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Autor(es):
Cavalcante da Cunha de Sa, Roberta Dourado [1] ; Simao, Jussara de Jesus [1] ; da Silva, Viviane Simoes [1] ; de Farias, Talita Mendes [1] ; Cruz, Maysa Mariana [1] ; Antraco, Vitor Jaco [1] ; Armelin-Correa, Lucia [1] ; Alonso-Vale, Maria Isabel [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, UNIFESP, BR-09913030 Diadema - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: NUTRIENTS; v. 13, n. 3 MAR 2021.
Citações Web of Science: 0
Resumo

This study aimed to investigate the effects of two commercially available fish oils (FOs) containing different proportions of two omega-3 fatty acids (FA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the metabolic and endocrine dysfunctions of white adipose tissue resulting from obesity. Male C57BL/6J mice, 8 weeks old, received a control or high-fat diet (CO and HF groups, with 9% and 59% energy from fat, respectively) for 8 weeks. The next 8 weeks, the HF group was subdivided into HF, HF+FO/E (HF+5:1 EPA:DHA), and HF+FO/D (HF+5:1 DHA:EPA). Supplementation was performed by gavage, three times a week. All groups that received the HF diet had lower food and caloric intake, but a higher fat intake, body weight (BW) gain, glucose intolerance, and a significant increase in inguinal (ING), retroperitoneal (RP), and epididymal (EPI) adipose tissues when compared to the CO group. Additionally, HF and HF+FO/D groups showed insulin resistance, adipocyte hypertrophy, increased lipolysis and secretion of TNF-alpha, resistin and IL-10 adipokines by ING and RP adipocytes, and adiponectin only by the HF+FO/D group in ING adipocytes. All of these effects were completely reversed in the HF+FO/E group, which also showed partial reversion in BW gain and glucose intolerance. Both the HF+FO/E and HF+FO/D groups showed a reduction in ING and RP adipose depots when compared to the HF group, but only HF+FO/E in the EPI depot. HF+FO/E, but not HF+FO/D, was able to prevent the changes triggered by obesity in TNF-alpha, Il-10, and resistin secretion in ING and RP depots. These results strongly suggest that different EPA:DHA ratios have different impacts on the adipose tissue metabolism, FO being rich in EPA, but not in DHA, and effective in reversing the changes induced by obesity. (AU)

Processo FAPESP: 17/08582-0 - Efeitos do tratamento com óleo de peixe sobre as disfunções metabólicas e endócrinas de adipócitos isolados de animais com síndrome metabólica
Beneficiário:Roberta Dourado Cavalcante da Cunha de Sá
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 18/05485-6 - Efeitos da dieta hiperlipídica e da suplementação com ácidos graxos ômega-7 e ômega-3 sobre o processo de browning, proliferação e diferenciação de células mesenquimais contidas na fração celular estromal do tecido adiposo
Beneficiário:Maria Isabel Cardoso Alonso-Vale
Linha de fomento: Auxílio à Pesquisa - Regular