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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of the bHLH transcription factor TCF21 in development and tumorigenesis

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Autor(es):
C.F.P. Lotfi [1] ; B.S. Passaia [2] ; J.L. Kremer [3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciências Biomédicas - Brasil
[2] Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciências Biomédicas - Brasil
[3] Universidade de São Paulo. Departamento de Anatomia. Instituto de Ciências Biomédicas - Brasil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Medical and Biological Research; v. 54, n. 5 2021-03-15.
Resumo

Transcription factors control, coordinate, and separate the functions of distinct network modules spatially and temporally. In this review, we focus on the transcription factor 21 (TCF21) network, a highly conserved basic-helix-loop-helix (bHLH) protein that functions to integrate signals and modulate gene expression. We summarize the molecular and biological properties of TCF21 control with an emphasis on molecular and functional TCF21 interactions. We suggest that these interactions serve to modulate the development of different organs at the transcriptional level to maintain growth homeostasis and to influence cell fate. Importantly, TCF21 expression is epigenetically inactivated in different types of human cancers. The epigenetic modification or activation and/or loss of TCF21 expression results in an imbalance in TCF21 signaling, which may lead to tumor initiation and, most likely, to progression and tumor metastasis. This review focuses on research on the roles of TCF21 in development and tumorigenesis systematically considering the physiological and pathological function of TCF21. In addition, we focus on the main molecular bases of its different roles whose importance should be clarified in future research. For this review, PubMed databases and keywords such as TCF21, POD-1, capsulin, tumors, carcinomas, tumorigenesis, development, and mechanism of action were utilized. Articles were selected within a historical context as were a number of citations from journals with relevant impact. (AU)

Processo FAPESP: 16/17285-6 - Análise da regulação epigenética do fator de transcrição POD1/TCF21 em culturas de células de tumores adrenocorticais, e seu papel na migração e invasão celular.
Beneficiário:Jean Lucas Kremer
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/12381-7 - Identificação de novos alvos do fator de transcrição POD1/TCF21 em culturas de células de tumores humanos
Beneficiário:Barbara dos Santos Passaia
Modalidade de apoio: Bolsas no Brasil - Doutorado