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Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Texto completo
Autor(es):
Tardelli, Lidieli P. [1] ; Duchatsch, Francine [1] ; Herrera, Naiara A. [1] ; Vicentini, Carlos Alberto [2] ; Okoshi, Katashi [3] ; Amaral, Sandra L. [4, 1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos - Brazil
[2] Sao Paulo State Univ UNESP, Sch Sci, Dept Biol, Bauru, SP - Brazil
[3] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Med Clin, Botucatu, SP - Brazil
[4] Sao Paulo State Univ Unesp, Sch Sci, Dept Phys Educ, Bauru, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF APPLIED TOXICOLOGY; FEB 2021.
Citações Web of Science: 0
Resumo

Dexamethasone (DEX)-induced hypertension is observed in normotensive rats, but little is known about the effects of DEX on spontaneously hypertensive animals (SHR). This study aimed to evaluate the effects of DEX on hemodynamics, cardiac hypertrophy and arterial stiffness in normotensive and hypertensive rats. Wistar rats and SHR were treated with DEX (50 mu g/kg s.c., 14 d) or saline. Pulse wave velocity (PWV), echocardiographic parameters, blood pressure (BP), autonomic modulation and histological analyses of heart and thoracic aorta were performed. SHR had higher BP compared with Wistar, associated with autonomic unbalance to the heart. Echocardiographic changes in SHR (vs. Wistar) were suggestive of cardiac remodeling: higher relative wall thickness (RWT, +28%) and left ventricle mass index (LVMI, +26%) and lower left ventricle systolic diameter (LVSD, -19%) and LV diastolic diameter (LVDD, -10%), with slightly systolic dysfunction and preserved diastolic dysfunction. Also, SHR had lower myocardial capillary density and similar collagen deposition area. PWV was higher in SHR due to higher aortic collagen deposition. DEX-treated Wistar rats presented higher BP (similar to 23%) and autonomic unbalance. DEX did not change cardiac structure in Wistar, but PWV (+21%) and aortic collagen deposition area (+21%) were higher compared with control. On the other side, DEX did not change BP or autonomic balance to the heart in SHR, but reduced RWT and LV collagen deposition area (-12% vs. SHRCT). In conclusion, the results suggest a differential effect of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats. (AU)

Processo FAPESP: 17/00509-1 - Papel do treinamento físico no balanço autonômico, rigidez arterial e rarefação em ratos espontaneamente hipertensos tratados com dexametasona: contribuição dos microRNAs
Beneficiário:Sandra Lia do Amaral Cardoso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/00567-4 - Influência da empaglifozina sobre o coração de ratos normais e com remodelação cardíaca induzida por infarto do miocárdio
Beneficiário:Katashi Okoshi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/12532-5 - A INFLUÊNCIA DO TREINAMENTO FÍSICO EM RATOS ESPONTANEAMENTE HIPERTENSOS TRATADOS COM DEXAMETASONA: CONTRIBUIÇÃO DOS MICRORNAs
Beneficiário:Naiara Araújo Herrera
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/14405-3 - Influência do treinamento físico aeróbio no remodelamento cardíaco de ratos espontaneamente hipertensos tratados com dexametasona
Beneficiário:Francine Duchatsch Ribeiro de Souza
Linha de fomento: Bolsas no Brasil - Mestrado