de Santana, Willian Max O. S.
Caetano, Bruno L.
[2, 3, 4]
de Annunzio, Sarah Raquel
Pulcinelli, Sandra H.
Fontana, Carla Raquel
Santilli, V, Celso
Número total de Autores: 7
Afiliação do(s) autor(es):
 V, Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP - Brazil
 Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
 Sorbonne Univ, PSL Univ, CNRS, ESPCI Paris, Soft Matter Sci & Engn, F-75005 Paris - France
 Sorbonne Univ, CNRS, PHENIX, Physicochim Electrolytes & Nanosyst Interfaciaux, F-75005 Paris - France
Número total de Afiliações: 4
Tipo de documento:
COLLOIDS AND SURFACES B-BIOINTERFACES;
Citações Web of Science:
In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photo-dynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm(-2), the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria. (AU)