Poly-epsilon-caprolactone Nanoparticles Loaded wit... - BV FAPESP
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Poly-epsilon-caprolactone Nanoparticles Loaded with 4-Nerolidylcatechol (4-NC) for Growth Inhibition of Microsporum canis

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Autor(es):
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Greatti, Vanessa Raquel [1] ; Oda, Fernando [1] ; Sorrechia, Rodrigo [1] ; Kapp, Barbara Regina [1] ; Seraphim, Carolina Manzato [1] ; Villas Boas Weckwerth, Ana Carolina [2] ; Chorilli, Marlus [1] ; Da Silva, Patricia Bento [1] ; Eloy, Josimar O. [3] ; Kogan, Marcelo J. [4, 5] ; Morales, Javier O. [4] ; Linhari Rodrigues Pietro, Rosemeire Cristina [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, BR-14800903 Araraquara, SP - Brazil
[2] Lauro Souza Lima Inst, Dept Mycol, BR-17034971 Bauru, SP - Brazil
[3] Univ Fed Ceara, Sch Pharm Dent & Nursing, Dept Pharm, Univ Ave, 2853 Rodolfo Te6filo, BR-60430160 Fortaleza, Ceara - Brazil
[4] Univ Chile, Sch Chem & Pharmaceut Sci, Santos Dumomt 964, Santiago 8380492 - Chile
[5] Adv Ctr Chron Dis, Sergio Livingstone 1007, Santiago 8380492 - Chile
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: ANTIBIOTICS-BASEL; v. 9, n. 12 DEC 2020.
Citações Web of Science: 0
Resumo

Dermatophyte fungal infections are difficult to treat because they need long-term treatments. 4-Nerolidylcatechol (4-NC) is a compound found in Piper umbellatum that has been reported to demonstrate significant antifungal activity, but is easily oxidizable. Due to this characteristic, the incorporation in nanostructured systems represents a strategy to guarantee the compound's stability compared to the isolated form and the possibility of improving antifungal activity. The objective of this study was to incorporate 4-NC into polymeric nanoparticles to evaluate, in vitro and in vivo, the growth inhibition of Microsporum canis. 4-NC was isolated from fresh leaves of P. umbellatum, and polymer nanoparticles of polycaprolactone were developed by nanoprecipitation using a 1:5 weight ratio (drug:polymer). Nanoparticles exhibited excellent encapsulation efficiency, and the antifungal activity was observed in nanoparticles with 4-NC incorporated. Polymeric nanoparticles can be a strategy employed for decreased cytotoxicity, increasing the stability and solubility of substances, as well as improving the efficacy of 4-NC. (AU)

Processo FAPESP: 16/02107-5 - Avaliação do potencial antimicrobiano in vitro e in vivo de extratos de Piper umbellatum incorporados ou não em sistemas lipídicos nanoestruturados
Beneficiário:Rosemeire Cristina Linhari Rodrigues Pietro
Modalidade de apoio: Auxílio à Pesquisa - Regular