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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hippocampal subregional volume changes in elders classified using positron emission tomography-based Alzheimer's biomarkers of beta-amyloid deposition and neurodegeneration

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Autor(es):
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Busatto Filho, Geraldo [1] ; Duran, Fabio Luiz de Souza [1] ; Squarzoni, Paula [1] ; Coutinho, Artur Martins Novaes [2] ; Rosa, Pedro Gomes Penteado [1] ; Torralbo, Leticia [1] ; Pachi, Clarice Gameiro da Fonseca [1] ; da Costa, Naomi Antunes [1] ; Porto, Fabio Henrique de Gobbi [1] ; Carvalho, Cleudiana Lima [1] ; Brucki, Sonia Maria Dozzi [3] ; Nitrini, Ricardo [3] ; Forlenza, Orestes Vicente [4] ; Leite, Claudia da Costa [5] ; Buchpiguel, Carlos Alberto [2] ; de Paula Faria, Daniele [2]
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Fac Med FMUSP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Radiol & Oncol, Lab Nucl Med LIM43, Fac Med FMUSP, Ctr Nucl Med Bldg, 2nd Floor, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Neurol, Fac Med FMUSP, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Psychiat, Lab Neurosci LIM 27, Fac Med FMUSP, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Radiol & Oncol, Lab Magnet Resonance Neuroradiol LIM44, Fac Med FMUSP, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Neuroscience Research; v. 99, n. 2, p. 481-501, FEB 2021.
Citações Web of Science: 0
Resumo

Changes in hippocampal subfield volumes (HSV) along the Alzheimer's disease (AD) continuum have been scarcely investigated to date in elderly subjects classified based on the presence of beta-amyloid aggregation and signs of neurodegeneration. We classified patients (either sex) with mild dementia compatible with AD (n = 35) or amnestic mild cognitive impairment (n = 39), and cognitively unimpaired subjects (either sex;n = 26) using {[}C-11]PIB-PET to assess beta-amyloid aggregation (A+) and {[}F-18]FDG-PET to account for neurodegeneration ((N)+). Magnetic resonance imaging-based automated methods were used for HSV and white matter hyperintensity (WMH) measurements. Significant HSV reductions were found in A+(N)+ subjects in the presubiculum/subiculum complex and molecular layer, related to worse memory performance. In both the A+(N)+ and A+(N)- categories, subicular volumes were inversely correlated with the degree of A beta deposition. The A-(N)+ subgroup showed reduced HSV relative to the A-(N)- subgroup also in the subiculum/presubiculum. Combining all (N)- subjects, HSV were lower in subjects presenting significant cognitive decline irrespective of A+/A- classification (controlling for WMH load); these between-group differences were detected again in the presubiculum, but also involved the CA4 and granular layer. These findings demonstrate that differential HSV reductions are detectable both in (N)+ and (N)- categories along the AD continuum, and are directly related to the severity of cognitive deficits. HSV reductions are larger both in A+(N)+ and A+(N)- subjects in direct proportion to the degree of A beta deposition. The meaningful HSV reductions detected in the A-(N)+ subgroup highlights the strength of biomarker-based classifications outside of the classical AD continuum. (AU)

Processo FAPESP: 18/15167-1 - Neuroimagem translacional na deficiência intelectual: avaliação de alterações moleculares associadas ao envelhecimento na Síndrome de Down
Beneficiário:Daniele de Paula Faria
Linha de fomento: Auxílio à Pesquisa - Jovens Pesquisadores