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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation

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Autor(es):
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Buzati Pereira, Bruna Leticia [1] ; Rodrigue, Alexane [2] ; de Oliveira Arruda, Fernanda Caroline [1] ; Bachiega, Tatiana Fernanda [1] ; Martins Lourenco, Maria Angelica [1] ; Correa, Camila Renata [1] ; Azevedo, Paula Schmidt [1] ; Polegato, Bertha Furlan [1] ; Okoshi, Katashi [1] ; Henrique Fernandes, Ana Angelica [3] ; Rupp de Paiva, Sergio Alberto [1] ; Mamede Zornoff, Leonardo Antonio [1] ; Power, Krista Anne [2] ; Minicucci, Marcos Ferreira [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ Unesp, Botucatu Med Sch, Internal Med Dept, Botucatu, SP - Brazil
[2] Univ Ottawa, Fac Hlth Sci, Sch Nutr Sci, Ottawa, ON - Canada
[3] Sao Paulo State Univ UNESP, Inst Biosci, Chem & Biochem Dept, Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; v. 24, n. 14, p. 7862-7872, JUL 2020.
Citações Web of Science: 1
Resumo

The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an infarcted group supplemented with 100 mg of SM/kg bodyweight/d, (MIS100; n = 23) and an infarcted group supplemented with 250 mg of SM/kg bodyweight/d (MIS250; n = 22). After 3 months of treatment, morphological, functional and biochemical analyses were performed. MI induced structural and functional changes in the left ventricle with worsening systolic and diastolic function, and SM supplementation at different doses did not influence these variables as analysed by echocardiography and an isolated heart study (P > .05). However, SM supplementation attenuated cardiac remodelling after MI, reducing fibrosis (P = .047) and hypertrophy (P = .006). Biomarkers of oxidative stress, inflammatory processes and energy metabolism were further investigated in the myocardial tissue. SM supplementation improved the efficiency of energy metabolism and decreased lipid hydroperoxide in the myocardium {[}group S (n = 8): 267.26 +/- 20.7; group MI (n = 8): 330.14 +/- 47.3; group MIS100 (n = 8): 313.8 +/- 46.2; group MIS250: 294.3 +/- 38.0 nmol/mg tissue; P = .032], as well as decreased the activation of the inflammatory pathway after MI. In conclusion, SM supplementation attenuated cardiac remodelling processes after MI. We also found that energy metabolism, oxidative stress and inflammation are associated with this effect. In addition, SM supplementation at the highest dose is more effective. (AU)

Processo FAPESP: 18/03082-1 - Efeitos da suplementação de feijão na saúde intestinal, microbioma e inflamação associada à obesidade em camundongos
Beneficiário:Bruna Letícia Buzati Pereira
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 15/18502-8 - Influência da suplementação de cajá na remodelação cardíaca após o infarto agudo do miocárdio
Beneficiário:Marcos Ferreira Minicucci
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/23215-5 - Influência da suplementação de cajá na remodelação cardíaca após o infarto agudo do miocárdio
Beneficiário:Bruna Letícia Buzati Pereira
Modalidade de apoio: Bolsas no Brasil - Doutorado