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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high-fat diet-induced obesity

Texto completo
Autor(es):
da Cunha de Sa, Roberta D. C. [1] ; Cruz, Maysa M. [1] ; de Farias, Talita M. [1] ; da Silva, Viviane S. [1] ; Simao, Jussara de Jesus [1] ; Telles, Monica M. [1, 2] ; Alonso-Vale, Maria Isabel C. [1, 2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Postgrad Program Chem Biol, Diadema, SP - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Diadema, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: PHYSIOLOGICAL REPORTS; v. 8, n. 4 FEB 2020.
Citações Web of Science: 0
Resumo

The effect of fish oil (FO) treatment on high-fat (HF) diet-induced obesity and metabolic syndrome was addressed by analyzing dysfunctions in cells of different adipose depots. For this purpose, mice were initially induced to obesity for 8 weeks following a treatment with FO containing high concentration of EPA compared to DHA (5:1), for additional 8 weeks (by gavage, 3 times per week). Despite the higher fat intake, the HF group showed lower food intake but higher body weight, glucose intolerance and insulin resistance, significant dyslipidemia and increased liver, subcutaneous (inguinal-ING) and visceral (retroperitoneal-RP) adipose depots mass, accompanied by adipocyte hypertrophy and decreased cellularity in both adipose tissue depots. FO treatment reversed all these effects, as well as it improved the metabolic activities of isolated adipocytes, such as glucose uptake and lipolysis in both depots, and de novo synthesis of fatty acids in ING adipocytes. HF diet also significantly increased both the pro and anti-inflammatory cytokines expression by adipocytes, while HF + FO did not differ from control group. Collectively, these data show that the concomitant administration of FO with the HF diet is able to revert metabolic changes triggered by the diet-induced obesity, as well as to promote beneficial alterations in adipose cell activities. The main mechanism underlying all systemic effects involves direct and differential effects on ING and RP adipocytes. (AU)

Processo FAPESP: 15/03554-2 - Os efeitos da suplementação com melatonina no quadro do desenvolvimento da obesidade em camundongos
Beneficiário:Talita da Silva Mendes de Farias Carvalho
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/07638-9 - Efeito da suplementação com melatonina no processo de transdiferenciação do tecido adiposo branco em tecido adiposo marrom em camundongos obesos
Beneficiário:Talita da Silva Mendes de Farias Carvalho
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
Processo FAPESP: 17/08582-0 - Efeitos do tratamento com óleo de peixe sobre as disfunções metabólicas e endócrinas de adipócitos isolados de animais com síndrome metabólica
Beneficiário:Roberta Dourado Cavalcante da Cunha de Sá
Linha de fomento: Bolsas no Brasil - Doutorado