Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Interleukin-6 and the Gut Microbiota Influence Melanoma Progression in Obese Mice

Texto completo
Autor(es):
Mostrar menos -
Pereira, V, Felipe ; Melo, Amanda C. L. [1] ; Silva, Marina B. [1] ; de Melo, Filipe M. [2] ; Terra, Fernanda F. [1] ; Castro, Iris A. [1] ; Perandini, Luiz A. [1] ; Miyagi, Marcelli T. [1] ; Sato, Fabio T. [3] ; Origassa, Clarice S. T. [1] ; Hiyane, I, Meire ; Donat Jr, Jose ; Wasinski, Frederick [4] ; Araujo, Ronaldo C. [4] ; Festuccia, William T. L. [5] ; da Silva, Joao Santana [6] ; Camara, Niels Olsen S. [7]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Pereira, Felipe, V, Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, EPM UNIFESP, Escola Paulista Med, Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Inst Biol, UNICAMP, Campinas, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, SP - Brazil
[5] Donat Jr, Jr., Jose, Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil
[7] Hiyane, Meire, I, Pereira, Felipe, V, Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 73, n. 4 MAY 2020.
Citações Web of Science: 0
Resumo

There is a strong correlation between obesity and cancer. Here, we investigated the influence of IL-6 and gut microbiota of obese mice in melanoma development. We first evaluated B16F10 melanoma growth in preclinical models for obesity: mice deficient for leptin (ob/ob) or adiponectin (AdpKO) and in wild-type mice (WT, C57BL/6J) fed a high-fat diet (HFD; 60% kcal from fat) for 12 weeks. The survival rates of ob/ob and HFD-fed mice were lower than those of their respective controls. AdpKO mice also died earlier than WT control mice. We then verified the involvement of IL-6 signaling in obese mice that were inoculated with melanoma cells. Both ob/ob and AdpKO mice had higher circulating IL-6 levels than wild-type mice. Melanoma tumor volumes in IL-6 KO mice fed an HFD were reduced compared to those of WT mice subjected to the same diet. Also evaluated the effect of microbiota in tumor development. Cohousing and fecal matter transfer experiments revealed that microbiota from ob/ob mice can stimulate tumor development in lean WT mice. Taken together, our data show that in some conditions IL-6 and the gut microbiota are key mediators that link obesity and melanoma. (AU)

Processo FAPESP: 13/10318-8 - Papel imunobiológico de adipocinas no melanoma murino experimental.
Beneficiário:Felipe Valença Pereira
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
Beneficiário:Niels Olsen Saraiva Câmara
Modalidade de apoio: Auxílio à Pesquisa - Temático