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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

P2X7 Receptor Signaling in Stress and Depression

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Autor(es):
Ribeiro, Deidiane Elisa [1] ; Roncalho, Aline Lulho [2, 3] ; Glaser, Talita [1] ; Ulrich, Henning [1] ; Wegener, Gregers [4, 5] ; Joca, Samia [3, 4, 6]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Chem Inst, Dept Biochem, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto - Brazil
[4] Aarhus Univ, Dept Clin Med, TNU, DK-8240 Risskov - Denmark
[5] Aarhus Univ, Dept Clin Med, AUGUST Ctr, DK-8000 Aarhus C - Denmark
[6] Aarhus Univ, AIAS, DK-8000 Aarhus C - Denmark
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 11 JUN 1 2019.
Citações Web of Science: 0
Resumo

Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required. Recent studies suggest that adenosine triphosphate (ATP)-mediated signaling through the P2X7 receptor (P2X7R) might play a prominent role in regulating depression-related pathology, such as synaptic plasticity, neuronal degeneration, as well as changes in cognitive and behavioral functions. P2X7R is an ATP-gated cation channel localized in different cell types in the central nervous system (CNS), playing a crucial role in neuron-glia signaling. P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate. Moreover, P2X7R stimulation in microglia modulates the innate immune response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, consistent with the neuroimmune hypothesis of MDD. Importantly, blockade of P2X7R leads to antidepressant-like effects in different animal models, which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans. This review will discuss recent findings linked to the P2X7R involvement in stress and MDD neuropathophysiology, with special emphasis on neurochemical, neuroimmune, and neuroplastic mechanisms. (AU)

Processo FAPESP: 15/13345-1 - Doença de Huntington: envolvimento de Huntingtin no controle do comprometimento celular
Beneficiário:Talita Glaser
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 12/50880-4 - Células-tronco: dos papéis de receptores de cininas e purinas às aplicações terapêuticas
Beneficiário:Alexander Henning Ulrich
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/08426-0 - Alcalóides indólicos, subprodutos do processamento de Maqui (Aristotelia chilensis) como aditivos alimentares no tratamento da Doença de Alzheimer
Beneficiário:Alexander Henning Ulrich
Linha de fomento: Auxílio à Pesquisa - Regular