Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chia flour (Salvia hispanica L.) did not improve the deleterious aspects of hyperlipidic diet ingestion on glucose metabolism, but worsened glycaemia in mice

Texto completo
Autor(es):
Mostrar menos -
de Miranda, Danielle Araujo [1] ; da Silva, Fernanda Pinheiro [1] ; Carnier, Marcela [1] ; Mennitti, Lais Vales [2] ; Figueredo, Raquel Galvdo [3] ; Losinskas Hachul, Ana Claudia [1] ; Boldarine, Valter Tadeu [1] ; Pinto Neto, Nelson Inacio [1] ; Seelaender, Marllia [3] ; Ribeiro, Eliane Beraldi [1] ; Oiler do Nascimento, Claudia Maria [1] ; Carnier, June [1] ; Oyama, Lila Missae [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Campus Baixada Santista, Santos, SP - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Food Research International; v. 121, p. 641-647, JUL 2019.
Citações Web of Science: 1
Resumo

Obesity is mainly caused by intake of a high-fat diet and sedentarism, and is considered a public health issue worldwide. Increased intestinal permeability may favour endotoxaemia generated by lipopolysaccharides, a substance present in the cell membrane of Gram-negative bacteria, and, consequently, an increase in systemic inflammation and metabolic diseases. In contrast (On the other hand), consumption of a healthy diet can help in the prevention and treatment of metabolic syndrome. In this way, Chia seeds (Salvia hispanica L), rich in polyunsaturated fatty acids, may present an anti-inflammatory role. In addition, chia is rich in antioxidants like caffeic and gallic acid and fiber. However, few studies have investigated the relationship between chia seeds, inflammatory mechanisms and intestinal permeability. Therefore, the aim of this study was to analyse the effects of chia administration on metabolism in obese mice. Swiss mice were fed a hyperlipidic diet either supplemented with or without 3% chia flour for 16 weeks. The results showed that supplementation could not reduce the deleterious effects of the lipid-rich diet in terms of body composition, glucose intolerance and activity of antioxidants enzymes in the liver. In addition, supplementation with chia in the control diet decreased the amount of occludin in the intestinal colon. In conclusion, although chia did not improve metabolic parameters it seemed to restore the intestinal barriers integrity. The beneficial effects of chia seem to be dependent of the quantity used, since our data conflict with those in the literature; however, it is important to note that other studies, unlike our protocol, used chia in the form of seeds or oil, and not flour. (AU)

Processo FAPESP: 13/12410-9 - Efeito da ingestão de chia (Salvia hispanica L.) na expressão de adipocinas e reguladores metabólicos no tecido adiposo, músculo esquelético e fígado de camundongos tratados com dieta hiperlipídica e hipercalórica
Beneficiário:June Carnier
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado