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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

Texto completo
Autor(es):
Kadir González ; Rosendo Diaz [2] ; Aurea F. Ferreira [3] ; Víctor García [4] ; Héctor Paz [5] ; José E. Calzada [6] ; Michelle Ruíz [7] ; Márcia Laurenti [8] ; Azael Saldaña
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: Revista do Instituto de Medicina Tropical de São Paulo; v. 60, 2018-02-15.
Resumo

ABSTRACT Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama. We analyzed 49 skin biopsy samples from patients with clinical suspicion of CL, by molecular tests (PCR for subgenus Viannia and HSP-70) and by Hematoxylin-Eosin staining. Samples were characterized at the species level by PCR-HSP-70/RFLP. From the 49 samples studied, 46 (94%) were positive by PCR and were characterized as Leishmania (V.) panamensis. Of these, 48% were positive by Hematoxylin-Eosin staining with alterations being observed both, in the epidermis (85%) and in the dermis (100%) of skin biopsies. The inflammatory infiltrate was characterized according to histopathological patterns: lymphohistiocytic (50%), lymphoplasmacytic (61%) and granulomatous (46%) infiltration, being the combination of these patterns frequently found. The predominant histopathological characteristics observed in CL lesions caused by L. (V.) panamensis in Panama were: an intense inflammatory reaction in the dermis with a combination of lymphohistiocytic, lymphoplasmacytic and granulomatous presentation patterns and the presence of ulcers, acanthosis, exocytosis and spongiosis in the epidermis. (AU)

Processo FAPESP: 17/03141-5 - Caracterização das alterações histopatológicas e da resposta imune celular em lesões cutâneas de pacientes com Leishmaniose tegumentar no Panamá
Beneficiário:Kadir Amilcar Gonzalez Carrion
Linha de fomento: Bolsas no Brasil - Doutorado Direto