Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex

Texto completo
Autor(es):
Coelho, Cesar A. O. [1] ; Ferreira, Tatiana L. [2] ; Kramer-Soares, Juliana C. [1] ; Sato, Joao R. [2] ; Oliveira, Maria Gabriela M. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo, SP - Brazil
[2] Univ Fed ABC, UFABC, Ctr Matemat Comp & Cognicao, Sao Bernardo Do Campo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: PLOS COMPUTATIONAL BIOLOGY; v. 14, n. 8 AUG 2018.
Citações Web of Science: 3
Resumo

Hippocampal damage results in profound retrograde, but no anterograde amnesia in contextual fear conditioning (CFC). Although the content learned in the latter have been discussed, alternative regions supporting CFC learning were seldom proposed and never empirically addressed. Here, we employed network analysis of pCREB expression quantified from brain slices of rats with dorsal hippocampal lesion (dHPC) after undergoing CFC session. Using inter-regional correlations of pCREB-positive nuclei between brain regions, we modelled functional networks using different thresholds. The dHPC network showed small-world topology, equivalent to SHAM (control) network. However, diverging hubs were identified in each network. In a direct comparison, hubs in both networks showed consistently higher centrality values compared to the other network. Further, the distribution of correlation coefficients was different between the groups, with most significantly stronger correlation coefficients belonging to the SHAM network. These results suggest that dHPC network engaged in CFC learning is partially different, and engage alternative hubs. We next tested if pre-training lesions of dHPC and one of the new dHPC network hubs (perirhinal, Per; or disgranular retrosplenial, RSC, cortices) would impair CFC. Only dHPC-RSC, but not dHPC-Per, impaired CFC. Interestingly, only RSC showed a consistently higher centrality in the dHPC network, suggesting that the increased centrality reflects an increased functional dependence on RSC. Our results provide evidence that, without hippocampus, the RSC, an anatomically central region in the medial temporal lobe memory system might support CFC learning and memory. (AU)

Processo FAPESP: 10/16295-1 - Influência do hipocampo na expressão de CREB e pCREB nos núcleos da amígdala após condicionamento de medo ao contexto
Beneficiário:Maria Gabriela Menezes de Oliveira
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/17619-0 - Análise de rede da aprendizagem do medo condicionado ao contexto na ausência do hipocampo
Beneficiário:Cesar Augusto de Oliveira Coelho
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/25755-2 - Rede neural subjacente à aquisição do condicionamento de medo em descontinuidade temporal e espacial: interações do córtex pré-límbico
Beneficiário:Maria Gabriela Menezes de Oliveira
Linha de fomento: Auxílio à Pesquisa - Regular