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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs

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Autor(es):
Vieira-Rasteli, Eveline Bis [1] ; de Paula, Bruna Balbino [1] ; de Paiva, Yara Bezerra [2] ; Coimbra, Norberto Cysne [2] ; Andrade Leite-Panissi, Christie Ramos [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Philosophy Sci & Literature Ribeirao Preto, Dept Psychol, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Physiology & Behavior; v. 194, p. 538-544, OCT 1 2018.
Citações Web of Science: 3
Resumo

Tonic immobility (TI) is an innate defensive response exhibited by prey when physical contact with a predator is prolonged and inescapable. This defensive response is able to activate analgesia mechanisms; this activation has adaptive value because, during an attack by a predator, the manifestation of recuperative behaviors can affect the appropriate behavioral defense strategy. Some studies have suggested that similar structures of the central nervous system can regulate the response of both TI and nociception. Thus, this study evaluated the effect of chemical lesion through the administration of ibotenic acid in restricted brain areas of the periaqueductal gray matter (PAG) in guinea pig on the TI response and nociception evaluated in the hot plate test before and after emission of TI. The data showed that an irreversible chemical lesion in the ventrolateral PAG reduced of the TI response as well as defensive antinociception. However, a lesion in the dorsal PAG blocked the defensive antinociception induced by TI but did not alter TI duration. In summary, one could hypothesize that the neural substrates responsible for defensive behavior and antinociception represent similar systems that are distinct in modulation. Thus, the ventrolateral PAG has been associated with the modulation of TI and the defensive antinociception induced by TI. In contrast, the integrity of the dorsal PAG should be necessary for defensive antinociception to occur but not to elicit TI behavior in guinea pigs. (AU)

Processo FAPESP: 07/06549-3 - Avaliação do comportamento defensivo de imobilidade tônica e da nocicepção após lesões restritas em estruturas do sistema cerebral aversivo.
Beneficiário:Eveline Bis Vieira Rasteli
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 05/00096-1 - Avaliação anátomo-funcional do comportamento defensivo de imobilidade tônica em cobaias
Beneficiário:Christie Ramos Andrade Leite Panissi
Linha de fomento: Auxílio à Pesquisa - Regular