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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils

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Autor(es):
Cassiano Silveira, Ana Paula [1] ; Kitabatake, Takae Tamy [1] ; Pantaleo, Vivian Mozol [1] ; Zangrossi Junior, Hello [2] ; Bertolino, Guilherme [1] ; de Oliveira Guirro, Elaine Caldeira [1] ; Dutra de Souza, Hugo Celso [1] ; de Araujo, Joao Eduardo [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biomech Med & Rehabil Locomotor Syst, Lab Neuropsychobiol & Motor Behav, AV Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Neuroscience Letters; v. 665, p. 170-175, FEB 5 2018.
Citações Web of Science: 0
Resumo

This study aims to investigate the frequency and total duration effects of the 2-week treadmill training after experimental ischemic stroke in the passive avoidance test. We performed bilateral occlusion of common external carotid arteries, for five minutes, in Mongolian gerbils. The training groups were: continuous training for twelve consecutive days or not continuous training for six non-consecutive days. The groups remained in the treadmill for 15 min, with the speed set at 10 m/min, and the training started 24 h after the stroke. In the Shuttle Box, each animal had ten trials during the Learning Session (LS), which occurred 24 h before the stroke. The Retention Test (RT) occurred 24 h after the stroke and started on the second, third, seventh and twelfth day after LS. After the experiments, the brains were perfused, and coronal sections of the CA1 area of the hippocampus were cut and stained with hematoxylin and eosin. ANOVA on Ranks was used for Behavioral data analysis and morphological data by percentage. Ischemic training groups showed preservation in neuron density in the CA1 area of the hippocampus, when compared to the control groups. Animals subjected to continuous training, showed a higher latency in the RT when compared to ischemic animals in both weeks {[}(2nd, H = 39.81; P < 0.05), (3rd, H = 38.08; P < 0.05), (7th, H = 44.17; P < 0.05), and (12th, H = 39.55; P < 0.05). Animals in the not continuous training showed higher latency in the RT, in the second week only {[}(2nd, H = 39.81; P < 0.05), (3rd, H = 38.08; P < 0.05), (7th, H = 44.17; P < 0.05), and (12th, H = 39.55; P < 0.05). These findings suggest that improvement of memory after stroke after treadmill training is dependent on the frequency and total duration of training. (AU)

Processo FAPESP: 05/02607-3 - Efeitos comportamentais e alterações apoptóticas neuroniais induzidos pelo treino de marcha forçada contínuo e intervalado em esteira pós-anóxia cerebral unilateral em Gerbilo
Beneficiário:João Eduardo de Araujo
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/07730-0 - Alterações Morfológicas e Comportamentais em Gerbilos Isquêmicos Induzidas Pela Exposição à Nicotina e Treino de Marcha Forçada Contínua em Esteira
Beneficiário:Takae Tamy Kitabatake
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 07/03077-3 - Efeitos comportamentais e repercussões na aquisição de memória produzidos pela estimulação forçada contínua crônica em esteira pós-isquemia cerebral global em gerbilos avaliados pelo teste de esquiva passiva
Beneficiário:Vivian Mozol Pantaleo
Linha de fomento: Bolsas no Brasil - Iniciação Científica