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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Trait-specific long-term consequences of genomic selection in beef cattle

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Autor(es):
de Rezende Neves, Haroldo Henrique [1, 2] ; Carvalheiro, Roberto [1] ; de Queiroz, Sandra Aidar [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, UNESP, Sch Agr & Vet Sci FCAV, Dept Zootecn, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP - Brazil
[2] GenSys Consultores Associados SS Ltda, Rua Guilherme Alves, 170 Cj 304, BR-90680000 Porto Alegre, RS - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Genetica; v. 146, n. 1, p. 85-99, FEB 2018.
Citações Web of Science: 0
Resumo

Simulation studies allow addressing consequences of selection schemes, helping to identify effective strategies to enable genetic gain and maintain genetic diversity. The aim of this study was to evaluate the long-term impact of genomic selection (GS) in genetic progress and genetic diversity of beef cattle. Forward-in-time simulation generated a population with pattern of linkage disequilibrium close to that previously reported for real beef cattle populations. Different scenarios of GS and traditional pedigree-based BLUP (PBLUP) selection were simulated for 15 generations, mimicking selection for female reproduction and meat quality. For GS scenarios, an alternative selection criterion was simulated (wGBLUP), intended to enhance long-term gains by attributing more weight to favorable alleles with low frequency. GS allowed genetic progress up to 40% greater than PBLUP, for female reproduction and meat quality. The alternative criterion wGBLUP did not increase long-term response, although allowed reducing inbreeding rates and loss of favorable alleles. The results suggest that GS outperforms PBLUP when the selected trait is under less polygenic background and that attributing more weight to low-frequency favorable alleles can reduce inbreeding rates and loss of favorable alleles in GS. (AU)

Processo FAPESP: 10/06185-4 - Estratégias para aumento de eficiência da seleção genômica em programas de melhoramento genético animal
Beneficiário:Haroldo Henrique de Rezende Neves
Linha de fomento: Bolsas no Brasil - Doutorado