Busca avançada
Ano de início
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice

Texto completo
Fantozzi, Evelyn Thais [1] ; Rodrigues-Garbin, Sara [1] ; Ricardo-da-Silva, Fernanda Yamamoto [2] ; Oliveira-Filho, Ricardo Martins [1] ; Spina, Domenico [3] ; Tavares-de-Lima, Wothan [1] ; Riffo-Vasquez, Yanira [3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Heart Inst InCor, Lab Cardiovasc Surg & Physiopathol Circulat LIM 1, Sao Paulo - Brazil
[3] Kings Coll London, Inst Pharmaceut Sci, Sackler Inst Pulm Pharmacol, 150 Stamford St, London SE1 9NH - England
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Pulmonary Pharmacology & Therapeutics; v. 49, p. 54-59, APR 2018.
Citações Web of Science: 1

Rational: Acute lung injury (ALI) is a common complication after intestinal ischemia and reperfusion (I/R) injury that can lead to acute respiratory distress syndrome (ARDS). We have previously demonstrated that females are protected against lung damage induced by intestinal I/R through an estrogen mediated mechanism. Objectives: To investigate the effect of obesity on ALI induced by intestinal I/R in female mice. Methods: C57B1/6 female mice were fed with a standard low-fat diet (SD) or a high-fat diet (HFD) for 9 weeks. Intestinal I/R injury was induced by a 45 min occlusion of the mesenteric artery followed by 2 and 24 h of reperfusion. Results: Significant increase in lung myeloperoxidase expression (MPO) and neutrophil numbers of SD and HFD mice occurred at 2 h and 24 h of reperfusion. Furthermore, HFD mice presented a significant increase in lung eosinophil peroxidase (EPO) expression and eosinophil numbers compared to SD mice. Lung wet/dry weight ratio was significantly greater in HFD mice at 2 and 24 h of reperfusion, accompanied by a significant increase in the expression of inducible NO in the lung tissue and a significant decrease in arterial oxygen saturation at 24 h of reperfusion relative to SD mice. Conclusion: Obesity predisposes female mice to increased pulmonary oedema and deterioration in gas exchange, which is accompanied by an increase in iNOS expression in the lung. (AU)

Processo FAPESP: 10/51330-2 - Obesity and sex hormones in lung injury
Beneficiário:Wothan Tavares de Lima
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/50550-4 - Obesity and sex hormones in lung injury
Beneficiário:Wothan Tavares de Lima
Modalidade de apoio: Auxílio à Pesquisa - Regular