Effects of N-acetylcysteine on isolated skeletal m... - BV FAPESP
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Effects of N-acetylcysteine on isolated skeletal muscle contractile properties after an acute bout of aerobic exercise

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Autor(es):
Jannig, Paulo R. [1] ; Alves, Christiano R. R. [1] ; Voltarelli, Vanessa A. [1] ; Bozi, Luiz H. M. [1, 2] ; Vieira, Janaina S. [1] ; Brum, Patricia C. [1] ; Bechara, Luiz R. G. [1, 2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 191, p. 46-51, DEC 15 2017.
Citações Web of Science: 0
Resumo

Aims: The current study tested the hypotheses that 1) an acute bout of aerobic exercise impairs isolated skeletal muscle contractile properties and 2) N-acetylcysteine (a thiol antioxidant; NAC) administration can restore the impaired muscle contractility after exercise. Main methods: At rest or immediately after an acute bout of aerobic exercise, extensor digitorum longus (EDL) and soleus muscles from male Wistar rats were harvested for ex vivo skeletal muscle contraction experiments. Muscles from exercised animals were incubated in Krebs Ringer's buffer in absence or presence of 20 mM of NAC. Force capacity and fatigue properties were evaluated. Key findings: Exercised EDL and soleus displayed lower force production across various stimulation frequencies (p < 0.001), indicating that skeletal muscle force production was impaired after an acute bout of exercise. However, NAC treatment restored the loss of force production in both EDL and soleus after fatiguing exercise (p < 0.05). Additionally, NAC treatment increased relative force production at different time points during a fatigue-induced protocol, suggesting that NAC treatment mitigates fatigue induced by successive contractions. Significance: NAC treatment improves force capacity and fatigue properties in ex vivo skeletal muscle from rats submitted to an acute bout of aerobic exercise. (AU)

Processo FAPESP: 08/57252-3 - Contribuicao do complexo enzimatico nad(p)h oxidase na atrofia muscular de ratos com insuficiencia cardiaca: influencia do treinamento fisico aerobico
Beneficiário:Luiz Roberto Grassmann Bechara
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/21065-3 - Adaptação mitocondrial induzida pelo exercício físico aeróbico: papel da mitofagia muscular
Beneficiário:Paulo Roberto Jannig
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/03016-8 - Caquexia do câncer: efeitos do treinamento físico aeróbio sobre o músculo esquelético em modelo animal
Beneficiário:Christiano Robles Rodrigues Alves
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto