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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Clinical and microbiological profile of chronic Burkholderia cepacia complex infections in a cystic fibrosis reference hospital in Brazil

Texto completo
da Costa Capizzani, C. P. [1] ; Cacador, N. C. [1] ; Torres, L. A. G. M. M. [2] ; Tonani, L. [1] ; Vandamme, P. [3] ; da Costa Darini, A. L. [4, 1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Bromatol, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Cyst Fibrosis Referral Serv, Clin Hosp, Ribeirao Preto - Brazil
[3] Univ Ghent, Microbiol Lab, Ghent - Belgium
[4] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Citações Web of Science: 2

Burkholderia sp. infections are extremely complex in cystic fibrosis (CF) patients, especially considering the lack of knowledge regarding its behavior, its relationship with prognosis, as well as its transmissibility and multidrug resistance features. This study evaluated the frequency of chronic infection by Burkholderia, using microbiological and clinical data. Ninety-eight patients with CF attended from July 2011 to April 2014 in a Brazilian reference hospital were included. Antimicrobial activity, molecular epidemiology, Shwachman score, body mass index, exacerbations, and lung function were analyzed. Nine patients had chronic colonization, and all of them showed preserved pulmonary function levels, body mass index, and Shwachman score. Meropenem was the most effective antibiotic; however, divergent results were shown by other studies. Cross-contamination may have occurred in only two unrelated patients of different ages, who were colonized by B. vietnamiensis, which does not occur frequently. Twelve new sequence types (STs) were identified and three STs have presented intercontinental distribution. None of the patients presented known epidemic strains. In conclusion, a relatively low number of patients with chronic colonization and suspected cross-infection were identified. Different from other studies that have found CF patients chronically colonized with Burkholderia sp. having a greater deterioration of lung function, more frequent antibiotic therapy, and increased mortality, in the current study, the patients showed good clinical outcomes and favorable options for antibiotics therapy. This study also updated the epidemiological database, which facilitates the multicentric collaborative analysis and assists in the control of global infection by these pathogens. (AU)

Processo FAPESP: 13/13455-6 - Epidemiologia das infecções bacterianas em pacientes com fibrose cística envolvendo Achromobacter e bactérias do complexo Burkholderia cepacia
Beneficiário:Carolina Paulino da Costa Capizzani
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 13/13358-0 - Epidemiologia clássica e molecular de Pseudomonas aeruginosa isoladas de pacientes com Fibrose Cística
Beneficiário:Natália Candido Caçador
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 14/14494-8 - Epidemiologia molecular de bactérias gram-negativas e genética da resistência a antibióticos
Beneficiário:Ana Lúcia da Costa Darini
Modalidade de apoio: Auxílio à Pesquisa - Temático