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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Nanotoxicity of graphene oxide: Assessing the influence of oxidation debris in the presence of humic acid

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Clemente, Zaira ; Castro, Vera Lucia S. S. ; Franqui, Lidiane S. ; Silva, Cristiane A. ; Martinez, Diego Stefani T.
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Environmental Pollution; v. 225, p. 118-128, JUN 2017.
Citações Web of Science: 16

This study sought to evaluate the toxicological effects of graphene oxide (GO) through tests with Danio rerio (zebrafish) embryos, considering the influence of the base washing treatment and the interaction with natural organic matter (i.e., humic acid, HA). A commercial sample of GO was refluxed with NaOH to remove oxidation debris (OD) byproducts, which resulted in a base washed GO sample (bw-GO). This process decreased the total oxygenated groups in bw-GO and its stability in water compared to GO. When tested in the presence of HA, both GO and bw-GO stabilities were enhanced in water. Although the embryo exposure showed no acute toxicity or malformation, the larvae exposed to GO showed a reduction in their overall length and acetylcholinesterase activity. In the presence of HA, GO also inhibited acid phosphatase activity. Our findings indicate a mitigation of material toxicity after OD removal. The difference in the biological effects may be related to the materials' bioavailability and biophysicochemical interactions. This study reports for the first time the critical influence of OD on the GO material biological reactivity and HA interaction, providing new data for nanomaterial environmental risk assessment and sustainable nanotechnology. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 14/12891-0 - Avaliação nanoecotoxicológica do óxido de grafeno
Beneficiário:Vera Lucia Scherholz Salgado de Castro
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/01995-9 - Avaliação nanoecotoxicológica do óxido de grafeno em Danio rerio (zebrafish): influência da interação com substâncias húmicas
Beneficiário:Zaira Clemente
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado