A critical discussion on diet, genomic mutations a... - BV FAPESP
Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A critical discussion on diet, genomic mutations and repair mechanisms in colon carcinogenesis

Texto completo
Autor(es):
Sakita, Juliana Yumi ; Gasparotto, Bianca ; Garcia, Sergio Britto ; Uyemura, Sergio Akira ; Kannen, Vinicius
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: Toxicology Letters; v. 265, p. 106-116, JAN 4 2017.
Citações Web of Science: 7
Resumo

Colon cancer is one of the most common malignancies and its etiology closely tied to dietary habits. Recent epidemiological data shows that colon cancer incidence is shifting to a much younger population. In this regard, some dietary components from a regular human meal might have various DNA-damaging compounds. Given that not every person endure cancer, the colonic malignancy develops throughout decades, and persistent DNA damage promotes cancer when induced at the proper intensity, a critical discussion of possible novel mechanisms by which carcinogens promote these tumors is urgently needed. Robust genomic sequencing analyses showed that low and late cell cycle expressed genes are prone to undergo mutation. Moreover, detection and repair mechanisms have a particular threshold to be activated throughout the G2/M phase, and reactivation of these devices during the M phase promotes genomic instability. Conditions of combined exposure to non-genotoxic concentrations of various carcinogens seem to act effectively through these weaknesses in genomic repair mechanisms. Therefore, we suggest that the natural tolerance of body defence mechanisms eventually become overwhelmed by the chronic exposure to different combinations and intensities of dietary mutagens leading to the high incidence of colon cancer in modern society. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 14/06428-5 - Como a sinalização serotoninérgica epitelial difere dos efeitos de sua síntese neural durante a inflamação associada ou não ao câncer de cólon
Beneficiário:Vinicius Kannen Cardoso
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores