Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chemopreventive effects of pequi oil (Caryocar brasiliense Camb.) on preneoplastic lesions in a mouse model of hepatocarcinogenesis

Texto completo
Autor(es):
Palmeira, Simone M. [1] ; Silva, Paula R. P. [1] ; Ferrao, Juliana S. P. [1] ; Ladd, Aliny A. B. L. [1] ; Dagli, Maria L. Z. [1] ; Grisolia, Cesar K. [2] ; Hernandez-Blazquez, Francisco J. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
[2] Univ Brasilia, Inst Biol Sci, Brasilia, DF - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: European Journal of Cancer Prevention; v. 25, n. 4, p. 299-305, JUL 2016.
Citações Web of Science: 6
Resumo

Pequi (Caryocar brasiliense Camb.), a fruit from Brazil's central region, was evaluated for its chemopreventive effects on preneoplastic liver lesions induced by the carcinogen diethylnitrosamine (DEN) in mice. BALB/c mice, 14 days of age, received an intraperitoneal injection at 10 mu g/g of DEN. The mice received either of two doses of pequi oil (100 or 400mg/kg) daily from the age of 30 days and were killed at the age of 189 days. Stereological parameters, including the volume density (V-v) and the total volume (V-tot) of the lesions (preneoplastic and adenomas), were measured and the expression of cytokeratins CK8/18 was evaluated. The total volume of lesions and adenomas was reduced by 51% in the group treated with the carcinogen and 400mg/kg of pequi oil administered daily by an oral gavage for 25 consecutive weeks. In addition, some mice in this group did not develop lesions. Among the remaining preneoplastic lesions in this group, the number of remodelled profiles increased by 2.4-fold in the 400-mg pequi oil-treated mice relative to the 100-mg-treated mice. Our results show that pequi oil exerts a hepatoprotective effect against DEN-induced development of preneoplastic lesions and adenoma in mice and the potential for its use in the prevention of liver cancer. (AU)

Processo FAPESP: 11/15415-6 - Avaliação do potencial quimiopreventivo do óleo de pequi (Caryocar brasiliense Camb,) pelo ensaio de média-duração
Beneficiário:Simone Morais Palmeira
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/50373-5 - Avaliação do potencial quimiopreventivo do óleo de pequi (Caryocar brasiliense Camb.) pelo ensaio de média-duração
Beneficiário:Francisco Javier Hernandez Blazquez
Linha de fomento: Auxílio à Pesquisa - Regular