| Texto completo | |
| Autor(es): |
Número total de Autores: 3
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 123, n. 2, p. 1013-1017, FEB 2016. |
| Citações Web of Science: | 6 |
| Resumo | |
The thermal behavior of the beta-blocker anti-hypertensive drug propranolol was investigated using thermoanalytical techniques TG-DTA, DSC and the evolved gas analysis by TG-FTIR, providing information regarding thermal stability, decomposition steps, melting point and heat of fusion of the compound. The results pointed for the decomposition in a single mass loss step, after melting. DSC data revealed that cold crystallization occurred in heat-cool-heat cycles, around 165 A degrees C. TG-FTIR presented 1-naphthol, isopropylamine and HCl as principal decomposition products. A tentative mechanism for the thermal behavior of propranolol is presented. (AU) | |
| Processo FAPESP: | 12/09911-3 - Aplicação de análise térmica ao estudo de fármacos antihipertensivos e antibióticos: beta-bloqueadores e tetraciclinas |
| Beneficiário: | Éder Tadeu Gomes Cavalheiro |
| Linha de fomento: | Auxílio à Pesquisa - Regular |