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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle

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Autor(es):
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Alexandre, Pamela A. [1, 2] ; Kogelman, Lisette J. A. [1] ; Santana, Miguel H. A. [2] ; Passarelli, Danielle [2] ; Pulz, Lidia H. [2] ; Fantinato-Neto, Paulo [2] ; Silva, Paulo L. [3] ; Leme, Paulo R. [3] ; Strefezzi, Ricardo F. [2] ; Coutinho, Luiz L. [4] ; Ferraz, Jose B. S. [2] ; Eler, Joanie P. [2] ; Kadarmideen, Haja N. [1] ; Fukumasu, Heidge [2]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, Copenhagen - Denmark
[2] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Anim Sci, Sao Paulo - Brazil
[4] Univ Sao Paulo, ESALQ, Dept Anim Sci, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 16, DEC 18 2015.
Citações Web of Science: 41
Resumo

Background: The selection of beef cattle for feed efficiency (FE) traits is very important not only for productive and economic efficiency but also for reduced environmental impact of livestock. Considering that FE is multifactorial and expensive to measure, the aim of this study was to identify biological functions and regulatory genes associated with this phenotype. Results: Eight genes were differentially expressed between high and low feed efficient animals (HFE and LFE, respectively). Co-expression analyses identified 34 gene modules of which 4 were strongly associated with FE traits. They were mainly enriched for inflammatory response or inflammation-related terms. We also identified 463 differentially co-expressed genes which were functionally enriched for immune response and lipid metabolism. A total of 8 key regulators of gene expression profiles affecting FE were found. The LFE animals had higher feed intake and increased subcutaneous and visceral fat deposition. In addition, LFE animals showed higher levels of serum cholesterol and liver injury biomarker GGT. Histopathology of the liver showed higher percentage of periportal inflammation with mononuclear infiltrate. Conclusion: Liver transcriptomic network analysis coupled with other results demonstrated that LFE animals present altered lipid metabolism and increased hepatic periportal lesions associated with an inflammatory response composed mainly by mononuclear cells. We are now focusing to identify the causes of increased liver lesions in LFE animals. (AU)

Processo FAPESP: 12/14792-3 - Caracterização da expressão gênica global associada à eficiência alimentar em bovinos Nelore
Beneficiário:Pâmela Almeida Alexandre
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/00307-1 - Abordagem de biologia de sistemas para o melhoramento da eficiência alimentar em bovinos Nelore
Beneficiário:Pâmela Almeida Alexandre
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
Processo FAPESP: 14/07566-2 - Genômica aplicada à produção de ruminantes
Beneficiário:José Bento Sterman Ferraz
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/02493-7 - Neoplasias mamárias de cadelas e a teoria das células-tronco cancerosas: uma abordagem comparada e translacional
Beneficiário:Heidge Fukumasu
Linha de fomento: Auxílio à Pesquisa - Jovens Pesquisadores