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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

METABOLIC EFFECTS OF EARLY PROTEIN UNDERNOURISHMENT AND RENOURISHMENT IN WISTAR RATS

Autor(es):
Baptista, Josemberg da Silva [1, 2] ; Cavalli, Marcelo Arthur [1] ; Luiz, Lucilene Ferreira [1] ; Vono, Diana de Oliveira [1] ; Seyfert, Carlos Eduardo [1, 3] ; Boldrini, Silvia de Campo [1] ; Liberti, Edson Aparecido [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, Lab Funct Anat Appl Clin & Surg LAFACC, Sao Paulo, SP - Brazil
[2] Univ Fed Espirito Santo, Dept Morphol, Lab Studies Appl Morphol LEMA, Vitoria, ES - Brazil
[3] Univ Fed Santa Maria, Dept Morphol, Santa Maria, RS - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BIOSCIENCE JOURNAL; v. 31, n. 5, p. 1561-1569, SEP-OCT 2015.
Citações Web of Science: 0
Resumo

Malnutrition remains an important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals. (AU)

Processo FAPESP: 06/56045-9 - Efeito da desnutricao proteica pre e pos-natal e da renutricao pos-natal sobre o crescimento craniofacial de ratos wistar nas fases puberal e adulta.
Beneficiário:Silvia de Campos Boldrini
Linha de fomento: Auxílio à Pesquisa - Regular