Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obesogenic Environment by Excess of Dietary Fats in Different Phases of Development Reduces Spermatic Efficiency of Wistar Rats at Adulthood: Correlations with Metabolic Status

Texto completo
Autor(es):
Reame, Vanessa [1] ; Pytlowanciv, Eloisa Zanin [1, 2] ; Ribeiro, Daniele Lisboa [3] ; Pissolato, Thiago Feres [1] ; Taboga, Sebastiao Roberto [1, 2] ; Goes, Rejane Maira [1, 2] ; Pinto-Fochi, Maria Etelvina [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Inst Biosci Letters & Exact Sci, Dept Biol, IBILCE UNESP, Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, UNICAMP, Campinas, SP - Brazil
[3] Fed Univ Uberlandia UFU, Inst Biomed Sci, Dept Histol, Uberlandia, MG - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BIOLOGY OF REPRODUCTION; v. 91, n. 6 DEC 1 2014.
Citações Web of Science: 19
Resumo

This study compares the impact of obesogenic environment (OE) in six different periods of development on sperm parameters and the testicular structure of adult rats and their correlations with sex steroid and metabolic scenario. Wistar rats were exposed to OE during gestation (O1), during gestation/lactation (O2), from weaning to adulthood (O3), from lactation to adulthood (O4), from gestation to sexual maturity (O5), and after sexual maturation (O6). OE was induced by a 20% fat diet, and control groups were fed a balanced diet (4% fat). Serum leptin levels and adiposity index indicate that all groups were obese, except for O1. Three progressive levels of impaired metabolic status were observed: O1 presented insulin resistance, O2 were insulin resistant and obese, and groups O3, O4, and O5 were insulin resistant, obese, and diabetic. These three levels of metabolic damage were proportional to the increase of leptin and decreased circulating testosterone. The impairment in the daily sperm production (DSP) paralleled these three levels of metabolic and hormonal damage being marginal in O1, increasing in O2, and being higher in groups O3, O4, O5, and O6. None of the OE periods affected the sperm transit time in the epididymis, and the lower sperm reserves were caused mainly by impaired DSP. In conclusion, OE during sexual maturation markedly reduces the DSP at adulthood in the rat. A severe reduction in the DSP also occurs in OE exposure during gestation/lactation but not in gestation, indicating that breast-feeding is a critical period for spermatogenic impairment under obesogenic conditions. (AU)

Processo FAPESP: 09/16071-9 - Efeitos da obesidade materna e supernutrição pós-natal sobre o aparelho genital masculino de ratos: avaliação morfofuncional das células de leydig
Beneficiário:Maria Etelvina Pinto Fochi
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/14815-8 - Efeitos de diferentes condições de obesidade sobre o aparelho genital masculino de ratos: avaliação da estrutura testicular e produção espermática
Beneficiário:Vanessa Reame
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 11/01612-4 - Efeitos da obesidade materna e supernutrição pós-natal sobre o aparelho genital masculino de ratos: avaliação morfofuncional das células de Leydig
Beneficiário:Rejane Maira Góes
Linha de fomento: Auxílio à Pesquisa - Regular