Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Exercise training, creatine supplementation, and bone health in ovariectomized rats

Texto completo
Autor(es):
Mostrar menos -
Murai, I. H. [1] ; Roschel, H. [1, 2] ; Pabis, L. V. S. [3] ; Takayama, L. [2] ; de Oliveira, R. B. [2, 4] ; dos Santos Pereira, R. T. [1] ; Dantas, W. S. [1] ; Pereira, R. M. R. [2] ; Jorgetti, V. [2] ; Ballester, R. Y. [3] ; Gualano, B. [1, 2, 5]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Dent, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Sch Med Sci, Campinas, SP - Brazil
[5] Escola Educ Fis & Esporte, Dept Biodinam Movimento Humano, BR-05508030 Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: OSTEOPOROSIS INTERNATIONAL; v. 26, n. 4, p. 1395-1404, APR 2015.
Citações Web of Science: 5
Resumo

Evidence suggests that creatine may have some beneficial effects on bone. The study aimed to investigate the effects of exercise alone or combined with creatine on bone health in ovariectomized rats. Findings show that exercise, but not creatine, has an important role in improving bone health. Introduction The aim of this study was to investigate the effects of exercise training alone or combined with creatine supplementation on bone health parameters in ovariectomized rats. Methods Wistar rats were randomly allocated into one of five groups: (i) sham-operated, (ii) ovariectomized non-trained placebo-supplemented, (iii) ovariectomized non-trained creatine- supplemented, (iv) ovariectomized exercise-trained placebo-supplemented, and (v) ovariectomized exercise-trained creatine-supplemented. Downhill running training and/or creatine supplementation (300 mg/kg body weight) were administered for 12 weeks. Bone mineral content (BMC), bone mineral density (BMD), and biomechanical and histomorphometric parameters were assessed. Results No interaction effects were observed for BMC and BMD at whole body, femur, and lumbar spine (p>0.05). Importantly, a main effect of training was detected for whole body BMC and BMD (p=0.003 and p<0.001, respectively), femoral BMC and BMD (p=0.005 and p<0.001, respectively), and lumbar spine BMC and BMD (p<0.001 and p<0.001, respectively), suggesting that the trained animals had higher bone mass, irrespective of creatine supplementation. Main effects of training were also observed for maximal load (p< 0.001), stiffness (p<0.001), and toughness (p=0.046), indicating beneficial effects of exercise training on bone strength. Neither a main effect of supplementation nor an interaction effect was detected for biomechanical parameters (p>0.05). No main or interaction effects were observed for any of the histomorphometric parameters evaluated (p>0.05). Conclusions Exercise training, but not creatine supplementation, attenuated ovariectomy-induced bone loss in this rat model. (AU)

Processo FAPESP: 12/04695-0 - Efeitos do exercício físico associado à suplementação de creatina na massa óssea de ratas ovariectomizadas
Beneficiário:Igor Hisashi Murai
Modalidade de apoio: Bolsas no Brasil - Mestrado